Synthesis of a New Diels-Alder Quinone Adduct and Its Use
in Preparing Thiazolo- and Oxazoloquinolines

Research Abstract
Syn (or anti) cinnamaldehydeoxime (1a, b) undergoes Diels-Alder addition to tetrabromo-p-benzoquinone (2) in dry xylene in 1 : 1 and 2 : 1 molar ratios to give the mono- and diadducts 3 and 4a, b respectively. The reaction of 3 with thioamides in ethanol gave thiazoloquinoline diones 6a-d, whereas with acid amides in ethylene glycol, it gave oxazoloquinolinediones 12a-f.
Research Authors
A. S. Hammam, M. S. K. Youssef,* Sh. M. Radwan, and M. A. Abdel-Rahman
Research Department
Department of chemistry
Research Journal
Bull. Korean Chem. Soc. ,
Research Member
Shaaban Mohamed Radwan Mohseb
Research Pages
, 779-785
Research Publisher
NULL
Research Rank
1
Research Vol
25(6),
Research Website
NULL
Research Year
2004

Synthesis of a New Diels-Alder Quinone Adduct and Its Use
in Preparing Thiazolo- and Oxazoloquinolines

Research Abstract
Syn (or anti) cinnamaldehydeoxime (1a, b) undergoes Diels-Alder addition to tetrabromo-p-benzoquinone (2) in dry xylene in 1 : 1 and 2 : 1 molar ratios to give the mono- and diadducts 3 and 4a, b respectively. The reaction of 3 with thioamides in ethanol gave thiazoloquinoline diones 6a-d, whereas with acid amides in ethylene glycol, it gave oxazoloquinolinediones 12a-f.
Research Authors
A. S. Hammam, M. S. K. Youssef,* Sh. M. Radwan, and M. A. Abdel-Rahman
Research Department
Department of chemistry
Research Journal
Bull. Korean Chem. Soc. ,
Research Member
Mohamed Salah Kamel Youssef
Research Pages
, 779-785
Research Publisher
NULL
Research Rank
1
Research Vol
25(6),
Research Website
NULL
Research Year
2004

Synthesis of Isomeric Pyridooxazinones, Pyridopyridazines and Triazolo-
pyridopyridazines from o-Aroylpyridinecarboxylic Acids.

Research Abstract
NULL
Research Authors
M.S.K. Youssef, A.F. Fahmy, M.S. Abdel Halim, M.A. Hassan and
J. Sauer.
Research Department
Department of chemistry
Research Journal
Org. Prep. Proced. Int.,
Research Member
Mohamed Salah Kamel Youssef
Research Pages
,247-256
Research Publisher
NULL
Research Rank
1
Research Vol
37(3),
Research Website
NULL
Research Year
2005

The Utility of Diaryl Sulfides and Diaryl Sulfones in Heterocyclic
Synthesis(1993-2003).

Research Abstract
NULL
Research Authors
M.M. Kandeel and M.S.K. Youssef.
Research Department
Department of chemistry
Research Journal
Phosphorus, Sulfur and Silicon,
Research Member
Mohamed Salah Kamel Youssef
Research Pages
,217-282
Research Publisher
NULL
Research Rank
1
Research Vol
180(1),
Research Website
NULL
Research Year
2005

Synthesis of Heterocycles Derived from 4-Amino-2(3-methyl-5-oxo-1-phenyl-2-pyrazolin-4-yl)-6-phenylpyrimidine-5-carbonitrile with Anticipated Biological Activity

Research Abstract
NULL
Research Authors
M.S.K. Youssef and R.A. Ahmed
Research Department
Department of chemistry
Research Journal
Afinidad
Research Member
Mohamed Salah Kamel Youssef
Research Pages
,315-320
Research Publisher
NULL
Research Rank
1
Research Vol
63(524),
Research Website
NULL
Research Year
2006

Synthesis of New Triphenodithiazine- and Indolocarbazolediones of Biological Interest

Research Abstract
NULL
Research Authors
A.S.Hammam, M.S.K. Youssef, F.M. Atta and Th.A.Mohamed
Research Department
Department of chemistry
Research Journal
Chemical Papers
Research Member
Mohamed Salah Kamel Youssef
Research Pages
292-299
Research Publisher
NULL
Research Rank
1
Research Vol
61(4),
Research Website
NULL
Research Year
2007

Synthesis of New Quinoxalinophenazinediones and Tetrahydrobenzodipyrrolo-tetrones of Biological Interest

Research Abstract
NULL
Research Authors
A.S.Hammam, M.S.K. Youssef, F.M. Attia and Th.A. Mohamed
Research Department
Department of chemistry
Research Journal
Chemical Papers
Research Member
Mohamed Salah Kamel Youssef
Research Pages
194-206
Research Publisher
NULL
Research Rank
1
Research Vol
62(2),
Research Website
NULL
Research Year
2008

Preparation and Reactions of 2-Methyl-7-(3-methyl-5-oxo-1-
phenyl-2-pyrazolin-4-yl)-5-arylthiazolo[3,2-a]pyrimido[4,5-d]oxazin-4(5H)-one

Research Abstract
Ethyl 7-amino-3-(3-methyl-5-oxo-1-phenyl-2-pyrazolin-4-yl)-5-aryl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate was hydrolyzed with an ethanolic sodium hydroxide and the sodium salt thus formed underwent cyclization with acetic anhydride to afford 2-methyl-7-(3-methyl-5-oxo-1-phenyl-2-pyrazolin-4-yl)-5-arylthiazolo[3,2-a]- pyrimido[4,5-d]oxazin-4(5H)-one. This compound was transformed to related heterocyclic systems via its reaction with various reagents. The biological activity of the prepared compounds was tested against Gram positive and Gram negative bacteria as well as yeast-like and filamentous fungi. They revealed in some cases excellent biocidal properties.
Research Authors
Youssef, Mohamed Salah K. Abbady, Mohamed S.
Ahmed, Ragaa A. Omar, Ahmed A.
Research Department
Department of chemistry
Research Journal
Chin. J. Chem,
Research Member
Ragaa Abo El-Wafa Ahmed Mahmoud
Research Pages
,1473-1482
Research Publisher
NULL
Research Rank
1
Research Vol
29,
Research Website
NULL
Research Year
2011

Preparation and Reactions of 2-Methyl-7-(3-methyl-5-oxo-1-
phenyl-2-pyrazolin-4-yl)-5-arylthiazolo[3,2-a]pyrimido[4,5-d]oxazin-4(5H)-one

Research Abstract
Ethyl 7-amino-3-(3-methyl-5-oxo-1-phenyl-2-pyrazolin-4-yl)-5-aryl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate was hydrolyzed with an ethanolic sodium hydroxide and the sodium salt thus formed underwent cyclization with acetic anhydride to afford 2-methyl-7-(3-methyl-5-oxo-1-phenyl-2-pyrazolin-4-yl)-5-arylthiazolo[3,2-a]- pyrimido[4,5-d]oxazin-4(5H)-one. This compound was transformed to related heterocyclic systems via its reaction with various reagents. The biological activity of the prepared compounds was tested against Gram positive and Gram negative bacteria as well as yeast-like and filamentous fungi. They revealed in some cases excellent biocidal properties.
Research Authors
Youssef, Mohamed Salah K. Abbady, Mohamed S.
Ahmed, Ragaa A. Omar, Ahmed A.
Research Department
Department of chemistry
Research Journal
Chin. J. Chem,
Research Member
Mohamed Saad Abbady hasanian
Research Pages
,1473-1482
Research Publisher
NULL
Research Rank
1
Research Vol
29,
Research Website
NULL
Research Year
2011
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