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Pyrazoles are five membered heterocycles constitute a higly significant class of compounds in organic synthesis. Nowadays, pyrazoles and condensed pyrazoles have attracted substantial attention of the scientists owing to their excellent pharmacological and agrochemical properties. Pyrazole derivatives exhibit a wide range of pharmacological effects such as: anticancer, antioxidant, anti-inflammatory, antipyretic, analgesic, antimicrobial, antidepressant, antiviral, antihypertensive, anti-glaucoma, anti-tubercular, sodium channel blocker, anxiolytic, neuroprotective and anti-diabetic activities. This review casts light on recent methodologies for the synthesis and reactions of thienopyrazole moiety. This follow-up may encourage scientists to create new routes towards the thienopyrazole nucleus with important biological activity.

Pyrazoles are five membered heterocycles constitute a higly significant class of compounds in organic synthesis. Nowadays, pyrazoles and condensed pyrazoles have attracted substantial attention of the scientists owing to their excellent pharmacological and agrochemical properties. Pyrazole derivatives exhibit a wide range of pharmacological effects such as: anticancer, antioxidant, anti-inflammatory, antipyretic, analgesic, antimicrobial, antidepressant, antiviral, antihypertensive, anti-glaucoma, anti-tubercular, sodium channel blocker, anxiolytic, neuroprotective and anti-diabetic activities. This review casts light on recent methodologies for the synthesis and reactions of thienopyrazole moiety. This follow-up may encourage scientists to create new routes towards the thienopyrazole nucleus with important biological activity.

Pyrazoles are five membered heterocycles constitute a higly significant class of compounds in organic synthesis. Nowadays, pyrazoles and condensed pyrazoles have attracted substantial attention of the scientists owing to their excellent pharmacological and agrochemical properties. Pyrazole derivatives exhibit a wide range of pharmacological effects such as: anticancer, antioxidant, anti-inflammatory, antipyretic, analgesic, antimicrobial, antidepressant, antiviral, antihypertensive, anti-glaucoma, anti-tubercular, sodium channel blocker, anxiolytic, neuroprotective and anti-diabetic activities. This review casts light on recent methodologies for the synthesis and reactions of thienopyrazole moiety. This follow-up may encourage scientists to create new routes towards the thienopyrazole nucleus with important biological activity.

Pyrazoles are five membered heterocycles constitute a higly significant class of compounds in organic synthesis. Nowadays, pyrazoles and condensed pyrazoles have attracted substantial attention of the scientists owing to their excellent pharmacological and agrochemical properties. Pyrazole derivatives exhibit a wide range of pharmacological effects such as: anticancer, antioxidant, anti-inflammatory, antipyretic, analgesic, antimicrobial, antidepressant, antiviral, antihypertensive, anti-glaucoma, anti-tubercular, sodium channel blocker, anxiolytic, neuroprotective and anti-diabetic activities. This review casts light on recent methodologies for the synthesis and reactions of thienopyrazole moiety. This follow-up may encourage scientists to create new routes towards the thienopyrazole nucleus with important biological activity.

The starting compound 4-amino-3-methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-
5-carboxamide (1), that has been previously synthesized according to the literature
procedure, underwent a reaction with the anhydride of phthalic acid
either in AcOH or DMF to give isoindolinylpyrazole-5-carboxamide 3 and
pyrazolothienopyrimidoisoindoledione 4, respectively. Also, it was subjected to
react with diethylmalonate followed by hydrazinolysis by hydrazine hydrate to
yield the pyrazolothienopyrimidinyl acetohydrazide 5. The carbohydrazide
derivative 5 was used as a key intermediate for the preparation of other new
heterocyclic systems containing pyrazolylacetyl pyrazolothienopyrimidines
and pyrazolothieno-pyrimidotriazepine compounds 6–11. The structures of
these new heterocycles have been characterized by using analytical and spectroscopic
analyses (IR, 1H-NMR, 13C-NMR and MS). Some derivatives of the
synthesized compounds exhibited remarkable antibacterial and antifungal
activities against many bacterial and fungal strains.

The starting compound 4-amino-3-methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-
5-carboxamide (1), that has been previously synthesized according to the literature
procedure, underwent a reaction with the anhydride of phthalic acid
either in AcOH or DMF to give isoindolinylpyrazole-5-carboxamide 3 and
pyrazolothienopyrimidoisoindoledione 4, respectively. Also, it was subjected to
react with diethylmalonate followed by hydrazinolysis by hydrazine hydrate to
yield the pyrazolothienopyrimidinyl acetohydrazide 5. The carbohydrazide
derivative 5 was used as a key intermediate for the preparation of other new
heterocyclic systems containing pyrazolylacetyl pyrazolothienopyrimidines
and pyrazolothieno-pyrimidotriazepine compounds 6–11. The structures of
these new heterocycles have been characterized by using analytical and spectroscopic
analyses (IR, 1H-NMR, 13C-NMR and MS). Some derivatives of the
synthesized compounds exhibited remarkable antibacterial and antifungal
activities against many bacterial and fungal strains.

The starting compound 4-amino-3-methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-
5-carboxamide (1), that has been previously synthesized according to the literature
procedure, underwent a reaction with the anhydride of phthalic acid
either in AcOH or DMF to give isoindolinylpyrazole-5-carboxamide 3 and
pyrazolothienopyrimidoisoindoledione 4, respectively. Also, it was subjected to
react with diethylmalonate followed by hydrazinolysis by hydrazine hydrate to
yield the pyrazolothienopyrimidinyl acetohydrazide 5. The carbohydrazide
derivative 5 was used as a key intermediate for the preparation of other new
heterocyclic systems containing pyrazolylacetyl pyrazolothienopyrimidines
and pyrazolothieno-pyrimidotriazepine compounds 6–11. The structures of
these new heterocycles have been characterized by using analytical and spectroscopic
analyses (IR, 1H-NMR, 13C-NMR and MS). Some derivatives of the
synthesized compounds exhibited remarkable antibacterial and antifungal
activities against many bacterial and fungal strains.