Interaction of 5-acetyl-8-quinolinol, corresponding 1-ethylquinolinium iodides, and 8-hydroxyquinoline-7-carbaldehyde with diethylmalonate under basic condition gave the corresponding of 4–6. Further reaction of 4–6 with hydrazine, phenyl hydrazine, hydroxylamine, urea, and/or thiourea gave the corresponding 1-[8-hydroxy-5(7)-quinolinyl]alkylidene-substituted heterocyclic derivatives (7–16) and corresponding 1-ethylquinolinium iodides (17–21). The structure of the synthesized compounds was confirmed by elemental and spectral analysis. The biological activity of 5-substituted 8-quinolinol was tested as microbicidal and bioregulator agents, the results obtained were interpreted according to their structure-activity relationships.

A new series of 2-aryl(alkyl)oxazoloquinolines (IV) were prepared by the reaction of 7-amino-8-hydroxyquinoline with aromatic (or aliphatic) aldehydes in the presence of piperidine as a catalyst. Interaction of 2-methyloxazolo[4,5-h]quinoIine with aromatic aldehydes in the presence of piperidine as a catalyst gave 2-stilbyloxazolo [4,5-h]quinolines. The structural configuration of the prepared compounds was determined by elemental and spectral analysis.