Some new sulphonyl-N-heterocyclo-8-hydroxy quinolines have been synthesised by the reaction of 8-hydroxyquinoline-5-sulphonyl hydrazide with different active methylene compounds. The pyrazole, pyrazoline, pyrazolidine and pyridazine derivatives were reacted with some metal cations to give the corresponding chelates. All synthesized compounds have been screened in vitro for their biological activities

Some new sulphonyl-N-heterocyclo-8-hydroxy quinolines have been synthesised by the reaction of 8-hydroxyquinoline-5-sulphonyl hydrazide with different active methylene compounds. The pyrazole, pyrazoline, pyrazolidine and pyridazine derivatives were reacted with some metal cations to give the corresponding chelates. All synthesized compounds have been screened in vitro for their biological activities

5-Cyano-4-oxo-6-phenyl-2-thioxo-l,2,3.4-tetrahydro pyrimidine1 (I) reacts with alkyl or alkaryl halides to give the corresponding 2-alkyl (alkaryl) derivatives (118-g); and with chloroacetic acid ethyl chloroacetate to give compounds 111 and IV respectively further reaction of IV with ammonia and amines yielded 5-cyano-2(glycolamidethio)-6-phenyl pyrimidine-4(3H) one derivatives (Va-g). The parent thiazolo[3,2-a]pyrimidine (VI) was prepared from compound 111 by refluxing with acetic anhydride. Also compound I reacted with hydrazine hydrate to give 2-hydrazino derivative IX was converted into a variety of triazolo(4.3-a] pyrimidine derivatives. The biological activity of the new compounds was tested as microbicidal and bioregulator agents, the results obtained were correlated with their structure

5-Cyano-4-oxo-6-phenyl-2-thioxo-l,2,3.4-tetrahydro pyrimidine1 (I) reacts with alkyl or alkaryl halides to give the corresponding 2-alkyl (alkaryl) derivatives (118-g); and with chloroacetic acid ethyl chloroacetate to give compounds 111 and IV respectively further reaction of IV with ammonia and amines yielded 5-cyano-2(glycolamidethio)-6-phenyl pyrimidine-4(3H) one derivatives (Va-g). The parent thiazolo[3,2-a]pyrimidine (VI) was prepared from compound 111 by refluxing with acetic anhydride. Also compound I reacted with hydrazine hydrate to give 2-hydrazino derivative IX was converted into a variety of triazolo(4.3-a] pyrimidine derivatives. The biological activity of the new compounds was tested as microbicidal and bioregulator agents, the results obtained were correlated with their structure

5-Cyano-4-oxo-6-phenyl-2-thioxo-l,2,3.4-tetrahydro pyrimidine1 (I) reacts with alkyl or alkaryl halides to give the corresponding 2-alkyl (alkaryl) derivatives (118-g); and with chloroacetic acid ethyl chloroacetate to give compounds 111 and IV respectively further reaction of IV with ammonia and amines yielded 5-cyano-2(glycolamidethio)-6-phenyl pyrimidine-4(3H) one derivatives (Va-g). The parent thiazolo[3,2-a]pyrimidine (VI) was prepared from compound 111 by refluxing with acetic anhydride. Also compound I reacted with hydrazine hydrate to give 2-hydrazino derivative IX was converted into a variety of triazolo(4.3-a] pyrimidine derivatives. The biological activity of the new compounds was tested as microbicidal and bioregulator agents, the results obtained were correlated with their structure

Pyridone and Thiopyridone derivatives (1) and (2) were considered as versatile intermediates to produce some interesting tricyclic compounds. They were converted to O- and S-alkylated pyridines (3) and (4) which undergo cycloaddition reaction to give the furo and thienopyridines. The thiopyridone derivative (2) react with bromodiethylmalonate to give S-diethoxycarbonyl-methane derivative 7 which are converted to S-pyrazolo compounds by reaction with hydrazine and phenylhydrazine