Do you have any questions? (088) 2080369 - 2345622 Pharmacy_QAAU@pharm.aun.edu.eg
Seminar of the pharmacist / Youstina Amin Malak - Teaching Assistant in South Valley University, who is registered for a master's degree in Pharmaceutical Sciences (Pharmacognosy)
under the title:-
“Pharmacognostical study of some species belong to Family (Asteraceae) cultivated in Egypt.”
On Monday, August 7, 2023, in the meeting room of the Pharmacognosy Department, at eleven o’clock in the morning.
God willing, the Clinical Pharmacy Department Council will hold its regular monthly meeting number (92) on Thursday, August 3, 2023, at twelve o'clock (noon).
in the meetings Hall of the Department - 5th floor (Building A)
In the department council meeting room
Malignant transformations are dependent on an aberrant increase in tubulin and microtubule activities for cancer cell growth, migration, invasion and metastasis. The present work includes design and synthesis of a new series of lipidated 1,3-diaryl propenones and their cyclized pyrimidine derivatives as tubulin polymerization inhibitors. These derivatives harness lipophilicity, ease of synthesis and antiproliferative activity of lipidated 1,3-diaryl propenones and their cyclized derivatives. New compounds were synthesized from 4′-hydroxyacetophenone via O-alkylation, condensation with different aromatic aldehydes followed by cyclization with urea, thiourea or guanidine. Cyclization of 1,3-diaryl propenones into 4,6-diaryl pyrimidines increased their antiproliferative activity with the most potent derivative 19 achieving IC50 values at low micro molar concentration against two human cancer cell lines; MCF-7 (breast cancer) and Hep-G (hepatic cancer)
