Efficient Solid Phase Synthesis of Sulfotyrosine Peptides using a Sulfate Protecting Group Strategy

Efficient Solid Phase Synthesis of Sulfotyrosine Peptides using a Sulfate Protecting Group Strategy

Research Abstract
Efficient Fmoc-based solid-phase synthesis (SPPS) of sulfotyrosine (sY) peptides is achieved by incorporating the sY residue(s) as a dichlorovinyl-protected (DCV) sulfodiester(s) and using 2-methylpiperidine for Fmoc removal. After removal of the other protecting groups, the DCV group could be cleaved by mild hydrogenolysis giving the sY peptides in good yield.
Research Authors
Ahmed M. Ali and Scott D. Taylor
Research Department
Department of Medicinal Chemistry
Research Journal
Angewandte Chemie International Edition
Research Member
Ahmed Magdy Ahmed Mohamed Ali
Research Publisher
NULL
Research Rank
1
Research Vol
48
Research Website
DOI: 10.1002/anie.200805642
Research Year
2009