Ligand-based design and synthesis of novel 3-spiro-2-oxindoline derivatives as potent VEGFR-2 inhibitors with antiproliferative activity and cell cycle arrest

Ligand-based design and synthesis of novel 3-spiro-2-oxindoline derivatives as potent VEGFR-2 inhibitors with antiproliferative activity and cell cycle arrest

Research Authors
Islam R. Sweify, Hend A.A. Abd El-Wahab, Wesam S. Qayed, Yasmine Hosny, Wael M. El-Sayed, José Rogério A. Silva, Tarek Aboul-Fadl
Research Date
Research Department
Department of Medicinal Chemistry
Research Journal
Bioorganic Chemistry
Research Member
islam ramadan Refai Sweifi
Hend Aboel-Magd Abdel-Moneim Abdel-Wahab
Wesam Saber Abdel-Aal Qayed
Tarek Aboul-Fadl Mohammad Hassan
Research Pages
110313 (1-21)
Research Publisher
Elsevier
Research Rank
Q1
Research Vol
181
Research Website
https://doi.org/10.1016/j.bioorg.2026.110313
Research Year
2026