God willing, the 65th meeting of the Department of Pharmacognosy Council at the Faculty of Pharmacy this will take place on Sunday, December 7, 2025, at 10:00 A.M.
in the department council meeting room.
Do you have any questions? (088) 2080369 - 2345622 Pharmacy_QAAU@pharm.aun.edu.eg
Nitrogen-doped carbon dots-based fluorescent nanoprobe for ultra-sensitive detection of travoprost acid in aqueous humor: Greenness and blueness assessment with intensive pharmacokinetic study
Research Abstract
Travoprost (TRV) is an efficient prostaglandin (PG) analogue, which is hydrolyzed by corneal esterases to its active acid form (TRV acid) after absorption. Till now no spectrofluorimetric methods have been reported for detection of TRV acid in biological fluids. Due to high sensitivity, simplicity and rapidity; a novel and ultra- sensitive spectrofluorometric method with an efficient solid phase extraction (SPE) technique was developed for determination of TRV acid in aqueous humor (AH). The study relies on the fluorescence enhancement of nitrogen-doped carbon dots (N-CDs), which were prepared via a hydrothermal treatment of triphenylamine and citric acid. The formed nanoprobe responds with very high sensitivity to trace amounts of TRV acid through hydrogen bonding formation, which is accompanied by an enhancement in fluorescence intensity due to N-CDs aggregation. The proposed method showed excellent sensitivity for analyzing TRV acid in the range of 1–200 ng/ mL, with a very low limit of detection (0.29 ng/mL). Additionally, the method’s selectivity for analyzing TRV acid in the presence of common ions and anticipated co-administered drugs was assessed. The structural and chemical properties of the prepared N-CDs were extensively characterized using X-ray diffraction (XRD), Fourier transform infrared (FT-IR) spectroscopy, Transmission electron microscopy (TEM), High resolution transmission electron microscopy (HRTEM) and X-ray photoelectron spectroscopy (XPS). Furthermore, the method’s appli cability was evaluated by studying the pharmacokinetic properties of TRV acid in AH. The environmental impact of the method was evaluated using various greenness assessment tools, confirming the eco-friendly nature of the proposed method.
Research Date
Research Department
Research File
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Research Journal
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
Research Member
Meeting of the Department of Pharmacognosy Council at the Faculty of Pharmacy this will take place on Sunday, December 7, 2025.
Meeting of the Council of the Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy this will take place on Sunday, December 7, 2025
God willing, The Pharmaceutical Analytical Chemistry Department Council will hold its regular monthly meeting No. (533) this will take place on Sunday, December 7, 2025, at 11:00 A.M
In the meetings Hall of the Department
A scientific discussion session was held to approve the research topic for the Master’s thesis of Pharmacist Taysir Ragab Bayoumi, Assistant Lecturer at the Department of Pharmacognosy, as part of the requirements for obtaining the Master’s Degree in Phar
God willing, on Sunday, December 7, 2025, a scientific discussion seminar will be held in the Department of Pharmacognosy to register the research topic for the Master's thesis of Pharmacist/Taisir Ragab Bayoumi, Teaching Assistant in the Department, for the degree of Master of Science in Pharmaceutical Sciences (Pharmacognosy), entitled:
Pharmacognostic and biological studies of Campsis radicans (L.) Bureau, Family Bignoniaceae, cultivated in Egypt.
This will take place in the meeting hall of the Department of Pharmacognosy at 10:00 AM.
Announcement For Second-Year Pharm-D Students Regarding the lecture scheduled on Monday, December 1, 2025, for the course: Pharmaceutical Organic Chemistry – 3
Important Announcement For Second-Year Pharm-D Students (General, Clinical, and National University) Regarding the Midterm Examination for the course: Pharmaceutical Organic Chemistry-3
The Research Ethics Committee at the Faculty of Pharmacy Organized a Lecture Entitled: “Biological Waste Management in Healthcare Facilities and Laboratories”
Under the patronage of Prof. Dr. Ahmed El-Menshawy, President of the University, and Prof. Dr. Gamal Badr, Vice President for Postgraduate Studies and Research, and under the supervision of Prof. Dr. Gehan Nabil Fateeh, Dean of the Faculty, Prof. Dr. Dina Fathallah Mohamed, Vice Dean for Postgraduate Studies and Research, and Prof. Dr. Tehani Hassan El-Fahham, Emeritus Professor of Pharmaceutics and Chairperson of the Faculty Research Ethics Committee, and in accordance with the training plan of the Committee, a lecture entitled “Biological Waste Management in Healthcare Facilities and Laboratories” was organized.
The event was attended by Prof. Dr. Noha Nahid Attia, Vice Dean for Community Service and Environmental Development, and Prof. Dr. Gilan Abdel-Razek Abdel-Aleem, Professor of Industrial Pharmacy and Director of the Quality Assurance and Accreditation Unit, along with department heads, faculty members, teaching assistants from various departments, and postgraduate students.
The lecture was delivered by Dr. Ehsan Mohamed Wagih, Lecturer in the Department of Microbiology and Immunology.
The event took place on Thursday, December 4, 2025.
Awareness Seminar Titled: “Connected… but Not Addicted: How to Use the Internet Without Letting It Use Us”
Under the patronage of Prof. Dr. Ahmed Al-Manshawy, President of the University, and Prof. Dr. Mohamed Ahmed Adawy, Vice President of the University for Community Service and Environmental Development, and under the supervision of Prof. Dr. Jihan Nabil Fetih, Dean of the Faculty, and Prof. Dr. Noha Nahidh Atiya, Vice Dean for Community Service and Environmental Development, the Community Service and Environmental Development Sector at the Faculty of Pharmacy organized an awareness seminar entitled:
“Connected… but Not Addicted: How to Use the Internet Without Letting It Use Us.”
The seminar was attended by Prof. Dr. Dina Fathallah Mohamed, Vice Dean for Postgraduate Studies and Research, Prof. Dr. Jilan Abdel-Razek Abdel-Aleem, Professor of Industrial Pharmacy and Director of the Quality Assurance and Accreditation Unit, in addition to a distinguished attendance of heads of departments, faculty members and their assistants, staff members, and students of the Faculty.
The seminar was delivered by Dr. Azza Khairy, PhD in Clinical Psychology and Psychologist at the Mental Health Hospital.
It is worth noting that the seminar shed light on how to use the internet consciously by setting specific time limits, defining clear goals for usage, focusing on purposeful content instead of random browsing, taking regular breaks, limiting device use at certain times, and using selected beneficial applications to reduce distraction.
At the conclusion of the seminar, Prof. Dr. Jihan Nabil Fetih, Dean of the Faculty, presented a certificate of appreciation to Dr. Azza Khairy, the seminar lecturer, in recognition of the valuable lecture and its topic, which concerns all segments of society, as well as the positive interaction of the audience with the seminar.
This event took place on Wednesday, 3/12/2025.
Design, Synthesis, Biological Evaluation, and In Silico Studies of New Nitazoxanide Derivatives: Toward Broad‐Spectrum Antimicrobial Agents
Research Abstract
Nitazoxanide (NTZ), an FDA-approved drug, served as the framework for synthesizing 22 new broad-spectrum antimicrobial agents from 4-aminosalicylic acid via protection–deprotection, Staudinger reduction, Clauson–Kaas pyrrole synthesis, and nucleophilic substitution. These compounds were evaluated for antibacterial, antimycobacterial, and antitrypanosomal activities. Several compounds, particularly 10, 11, 13, and 22, surpassed the antibacterial activity of NTZ and its active metabolite tizoxanide (TIZ) against all tested pathogens, with MICs ranging from 1.025 to 9.81 μM. Compounds 10 and 13 were twice as potent as ciprofloxacin against Klebsiella pneumoniae, while 11 and 17 were equipotent against Pseudomonas aeruginosa (MIC 5.34 μM). Compounds 11 and 14 matched ciprofloxacin against Staphylococcus aureus (MIC 3.20 and 2.98 µM), whereas 13 and 21 were 1.5- and 2.5-fold more potent against Enterococcus faecalis, respectively. Compound 10 outperformed ciprofloxacin against Helicobacter pylori (MIC 1.025 μM). Compounds 6 (MIC 9.46 μM) and 7 (MIC 16.78 μM) outperformed NTZ against Mycobacterium tuberculosis, and compound 3 emerged as a promising antitrypanosomal agent (MICs 2.59–4.73 μg/mL) against six Trypanosoma species. Cytotoxicity and pharmacokinetic studies confirmed the compounds’ favorable drug-like properties and high selectivity. Docking results showed strong binding to key targets like pyruvate ferredoxin oxidoreductase (PFOR), glucosamine-6-phosphate synthase (G6PS), dihydrofolate reductase (DHFR), and ornithine decarboxylase (ODC). Overall, several NTZ derivatives, particularly compounds 3, 6, 10, 11, 13, and 22, showed potent broad-spectrum antimicrobial activity and offer convenient leads for further optimization.
Research Date
Research Department
Research Journal
Archiv der Pharmazie
Research Member
Research Pages
70091
Research Publisher
Wiley Online Library
Research Vol
358
Research Website
https://onlinelibrary.wiley.com/doi/abs/10.1002/ardp.70091
Research Year
2025