Cytarabine is one of the potent chemotherapeutic drugs that has many cytotoxic side effects. Our study was conducted to evaluate the possible ability of systemically injected bone marrow mesenchymal stem cells (BMMSCs) to ameliorate the cytotoxicity caused by Cytarabine in the submandibular salivary glands of rats.
Methods: 30 albino male rats with weights of 200–250 g were divided equally into three groups. Group I (control group). Group II (Cytarabine group) at a dose of 100 mg/kg for five consecutive days. Group III (Cytarabine and BMMSCs): BMMSCs were administered intravenously via the tail vein one day after the last dose of the Cytarabine drug at a dose of 1.5 million cells/body. After 6 days, the rats were sacrificed, and the submandibular salivary glands were dissected out. The glands were prepared for histological and immunohistochemical examination.
Results: Upon examination, Group II showed atrophied acini with cytoplasmic vacuolization. Dilatation of the striated ducts and stagnation of the secretory material in their lumen, the nuclei of the ductal cells showed pyknosis. Meanwhile, Group III showed well-arranged acini and nearly normal ducts. Immunohistochemical results using anti-caspase-3 antibodies showed improvement in Group III over Group II; there was a significant difference between the optical densities of Group II and Group III.

ABSTRACT

Objective: This study aimed to assess the effect of various surface treatments on the push-out bond strength of custom-made PolyEtherEtherketone(PEEK) and prefabricated glass fiber posts after being treated with different surface treatment materials.

Materials and methods: Sixty single rooted upper central incisors that were recently extracted were selected. All root canals were endodontically treated and post spaces prepared then divided into two equal groups based on posts type. Prefabricated glass fiber posts (n=30) were used in the first group(G), while milled PolyEtherEtherketone posts (n=30) were used in the second group(P). Based on surface treatment, each post group was randomly divided into three equal subgroups: subgroup(SB): sandblasting with 50µm Aluminum-oxide particles, subgroup(SE): etching with 98% Sulfuric acid and subgroup(HE+SC): etching using 9.5% hydrofluoric acid followed by silane coating. All post surfaces were examined using a scanning electron microscope (SEM). All posts were bonded with self-adhesive resin cement according to manufacturer instructions. All samples were sectioned into; coronal, middle and apical sections with a thickness of 2 mm each. Then, push-out test was carried out on the samples using a universal testing machine. Finally, the data were statistically analyzed.

Results: There was a statistically significant difference (P=0.002) with the mean push-out value higher in glass fiber than PEEK post (4.18±1.72MPa vs. 2.65±2.12MPa, respectively).

Conclusion: The glass fiber post’s bond strength was higher than that of the PEEK posts. PEEK posts that were sandblasted with aluminum-oxide particles showed a noticeable improvement in bonding and would be a good choice for PEEK post surface treatment

ABSTRACT

Purpose: This research aimed to compare translucency of lithium disilicate glass ceramic and high translucent monolithic zirconia using different finishing techniques and after being exposed to a corrosive medium.

Materials and Methods: Two main ceramic materials, Lithium Di-silicate (IPS e.max CAD LT A3, C14) and High Translucent Zirconia (HTZ) from DD BioZx2 A3-HT, along with acetic acid as a corrosive agent was employed in this study. Forty ceramic discs(10x12mm) were classified into two groups (20 discs each) according to the type of ceramic used then each group was subdivided into two subgroups (10 discs each) according to the finishing procedure (glazed and polished) then each disc was tested for translucency parameter. All discs were immersed in 4% acetic acid as a corrosive agent to study the effect of aging on translucency of glazed and polished ceramic.

Results: In terms of translucency parameter (TP), both glazed and polished subgroups of E-max samples exhibited statistically no significant difference after corrosion (p-value=0.149). Similar trends were observed in HTZ samples (p-value=0.853). Additionally, when comparing glazed samples between E-max and HTZ, Results showed that there was no statistically significant difference between both materials (E-max/HTZ) p-value=0.067. While for the polished samples there was statistically significant difference between both materials (E-max/HTZ) favoring the superior translucency of polished E-max samples over HTZ ones. p-value=0.029.

Conclusions: The translucency parameter (TP) of the studied materials is not significantly affected by the finishing procedure (mechanical polishing or glazing). But compared to glazing, mechanical polishing produced better translucency outcomes for the examined samples. Also corroded E-max exhibits superior translucency in comparison to HTZ.

ABSTRACT

Purpose: This research aimed to compare lithium disilicate glass ceramic and high translucent monolithic zirconia using different finishing techniques and after being exposed to a corrosive medium.

Materials and Methods: Two main ceramic materials, Lithium Di-silicate (IPS e.max CAD LT A3, C14) and High Translucent Zirconia (HTZ) from DD BioZx2 A3-HT, along with acetic acid as a corrosive agent was employed in this study. Forty ceramic discs(10x12mm) were classified into two groups (20 discs each) according to the type of ceramic used then each group was subdivided into two subgroups (10 discs each) according to the finishing procedure (glazed and polished) each disc was tested for color stability. All discs were immersed in 4% acetic acid as a corrosive agent to study the effect of aging on color stability of glazed and polished ceramic.

Results: In terms of color stability (∆E), both glazed and polished subgroups of E-max samples exhibited statistically significant differences after corrosion, favoring the superior color stability of glazed over polished ones (p-value=0.001). Similar trends were observed in HTZ samples, with glazed samples demonstrating better stability (p-value=0.003). Additionally, when comparing glazed samples between E-max and HTZ, the HTZ group showed significantly better color stability (p-value=0.001). The same pattern was found in polished samples, favoring HTZ over E-max (p-value=0.001).

Conclusions: Corrosion of samples exerted a notable impact on the color stability of the tested Lithium Di-silicate (E-max) and High Translucent Zirconia (HTZ) ceramics, irrespective of the finishing techniques employed. The method of finishing played crucial roles, with glazed HTZ samples demonstrating the least susceptibility to corrosion in terms of color stability.