Background and Aim: Ophiotaenia species are globally distributed proteocephalidean cestodes that commonly parasitize amphibians and reptiles. Despite the ecological importance of frogs in controlling insect populations and maintaining foodweb stability, data on cestode infections in Egyptian amphibians remain scarce. This study provides the first documentation of Ophiotaenia sp. infecting Amietophrynus kassasii in Egypt and evaluating the in vitro anticestodal activity of Sinularia sp. extract against adult tapeworms.