The increasing presence of pharmaceutical contaminants, particularly daclatasvir (DCV) in wastewaters poses significant environmental and health concerns. This study explores synthesis and application of a PEG6000@AlBDC nanocomposite as an effective adsorbent for DCV abatement from aqueous solutions. The nanocomposite was prepared by integrating polyethylene glycol (PEG6000) with aluminum-based benzene dicarboxylate MOF (Al-BDC). Comprehensive characterization of the compounds was conducted employing various techniques, including Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and transmission electron microscopy (TEM). The adsorption experiments assessed the impact of contact time, pH, adsorbent dosage, and initial DCV concentration on the removal efficiency. The results highlight that the PEG6000@Al-BDC nanocomposite exhibited a high adsorption capacity for DCV, achieving optimal removal of 93.9 % at pH 6.5, as compared to 38.0 % DCV removal using the un-modified MOF. Adsorption kinetics followed a pseudo-second-order model, whilst equilibrium data were aligned well with Langmuir isotherm, indicating monolayer adsorption. Thermodynamic studies suggested that the adsorption process was spontaneous and exothermic. The findings demonstrate that PEG6000@Al-BDC is a promising adsorbent for DCV removal, showcasing a potential solution for the mitigation of pharmaceutical pollutants in wastewater treatment systems.