Novel Heterocyclic Hybrids Based on 2-Pyrazoline: Synthesis and Assessment of Anti-Inflammatory and Analgesic Activities

Novel Heterocyclic Hybrids Based on 2-Pyrazoline: Synthesis and Assessment of
Anti-Inflammatory and Analgesic Activities

Research Abstract

Abstract: A series of new 2-pyrazoline analogues was synthesized. The structures of the synthesized
compounds were elucidated by the analytical and spectroscopic data. Some selected compounds were screened
for the anti-inflammatory activity by using the animal model of carrageenan-induced paw edema in mice.
Additionally, the analgesic and acute toxicity of these compounds were evaluated and exhibited reasonable
results. The anti-oxidant and anti-inflammatory effects of these compounds were established by measuring the
contents of malondialdehyde (MDA), reduced glutathione (GSH), nitric oxide (NO), and tumor necrosis factor
alpha (TNF-α) in the edema paw tissue. The results revealed that compounds 5, 6, 7, and 15 could be
recognized as potential multi-potent anti-inflammatory agents.

Research Authors
Ahmed Abdou O. Abeed, Gehad A. Abdel Jaleel and Mohamed Salah K. Youssef
Research Department
Department of chemistry
Research Journal
current organic synthesis
Research Member
Mohamed Salah Kamel Youssef
Research Pages
10
Research Publisher
bentham16
Research Rank
1
Research Vol
16
Research Website
https://www.eurekaselect.com/node/173203/article/novel-heterocyclic-hybrids-based-on-2-pyrazoline-synthesis-and-assessment-of-anti-inflammatory-and-analgesic-activities
Research Year
2019