ABSTRACT This study investigates the complex dehydration kinetics of sodium sulfate decahydrate (Na2 SO4 .10H2 O). Analysis of TG/DTG data reveals that the dehydration process proceeds via five complex steps. Using isoconversional methods (FR, FWO, and DAEM), the kinetic parameters (Ea and ln A) of the individual steps were obtained. The Ea − α plots revealed that all deconvoluted processes are driven by a single reaction mechanism identified as a diffusion model (D3 ). A significant linear relationship between ln A and Ea with similar isokinetic temperatures characterized the kinetic compensation effect. Thermodynamic analysis indicates that the entire conversion is an endothermic and non-spontaneous process.