Synthesis of 5-Phenyl-1-(3-pyridyl)-1H-1,2,4-triazole-3-carboxylic Acid Derivatives of Potential Anti-inflammatory Activity.

Research Authors
Safwat M. Rabea, Nawal A. El-Koussi, Hoda Y. Hassan, Tarek Aboul-Fadl
Research Department
Department of Medicinal Chemistry
Research Journal
Arch. Pharm. Chem.Life Sci.
Research Member
Hoda Youssef Hassan Huosien
Research Rank
1
Research Vol
339
Research Year
2006

The Utility and Synthetic Uses of Mannich Reaction: An efficient Route for Synthesis of Thiadiazino-[1,3,5][3,2-a]Benzimidazoles.

Research Authors
Abdel-Wareth A.O. Sarhan, Shams H. Abdel-Hafez, Hassan El-Sherif and Tarek Aboul-Fadl
Research Department
Department of Medicinal Chemistry
Research Journal
Synthetic Communications
Research Member
Tarek Aboul-Fadl Mohammad Hassan
Research Rank
1
Research Vol
36
Research Year
2006

Sensitivity of Escherichia coli to L-selenaproline and other L-proline analogues in laboratory culture media and normal. human urine Charles Deutch.

Research Authors
Maria Arballo, Latoya Cooks, Jenny Gomes, Tiara Williams, Tarek Aboul-Fadl and Jeanette Roberts
Research Department
Department of Medicinal Chemistry
Research Journal
Letters in Applied Microbiology
Research Member
Tarek Aboul-Fadl Mohammad Hassan
Research Rank
1
Research Vol
43
Research Year
2006

Quantitative Structure-Activity Relationship (QSAR) Studies
on a Series of 1,3,4-thiadiazole-2-thione Derivatives as
Tumor-Associated Carbonic Anhydrase IX Inhibitors

Research Abstract
A linear quantitative structure–activity relationship (QSAR) study that encodes various aspects of physicochemical,topological and electronic descriptors has been developed for a series of 1,3,4-thiadiazole-2-thione derivatives (1a-r and 2a-c). The carbonic anhydrase IX inhibitory activity of the candidates under study (1a-r and 2a-c) were correlated to the selected parameters using stepwise linear regression analyses to achieve the best QSAR model. Promising results were obtained with the employed tetra-parametric model indicating that the information approach used in the present investigation is quite useful for modeling carbonic anhydrase IX inhibitors.
Research Authors
Mohammed K. Abdel-Hamid, Atef A. Abdel-Hafez, Nawal A. El-
Koussi, Nadia M. Mahfouz
Research Department
Department of Medicinal Chemistry
Research Journal
Journal of Enzyme Inhibition and Medicinal Chemistry
Research Member
Nadia Mohamed Ahmed Mahfouz
Research Publisher
Taylor & Francis Group
Research Rank
1
Research Vol
vol. 24 - No. 3
Research Website
NULL
Research Year
2009
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