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Community Service and Environmental Development Sector for the Academic Year 2022/2023 of the Faculty of Pharmacy announces the holding of a symposium entitled Climate Changes in the Pharmacy Eyes
Meeting of the Executive Committee (Clinical Pharmacy Program) on Sunday, November 13, 2022 at 10 AM
God willing, The Executive Committee meeting will be held on Sunday, November 13, 2022 at 10 AM the Faculty Council Hall - the fifth floor (administrative building)
Dean of the Faculty
(Prof. Ahmed Mohamed Abdel Mawla)
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خبر عام
Meeting of the committee for community and environmental development at the Faculty of Pharmacy on Monday, November 14, 2022 at ten (AM)
God willing, A meeting of the committee for community and environmental development will hold on Monday, November 14, 2022 at 10:00 (AM)
In the office of Vice Dean for Community Services and Environmental Development Affairs.
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A meeting of the laboratories and scientific equipment committee at the Faculty of Pharmacy on Monday, November 14, 2022 AD at 11:00 (AM)
God willing, the laboratories and scientific equipment committee will hold its meeting on Monday, November 14, 2022 AD at 11:00 (AM)
in the office of Vice Dean for Community Services and Environmental Development Affairs.
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خبر عام
Meeting of the Council of the Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy on Tuesday, November 8, 2022 at eleven o'clock
God willing, the Pharmaceutical Organic Chemistry Department Council will hold its regular monthly meeting number (452) onTuesday, November 8, 2022 at eleven o'clock
In the department council meeting room.
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Meeting of the Council of the Clinical Pharmacy Department, Faculty of Pharmacy on Sunday, November 6, 2022, at ten (AM)
God willing, the Clinical Pharmacy Department Council will hold its regular monthly meeting number (83) on Sunday, November 6, 2022, at ten (AM)
in the office of Prof. Dr. Dean of the College of Pharmacy
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Student Selection Contest At the faculty level for the academic year 2022/2023
Under the auspices of Prof. Dr. Ahmed El-Minshawy - President of the University, Prof. Dr. / Ahmed Mohamed Abdel Mawla - Dean of the faculty and Vice President for Education and Student Affairs, and under the supervision of Prof. Dr. / Hassan Refaat Hassan - Vice Dean for Education and Student Affairs and Chairman of the Committee arbitration, The Youth Welfare Department at the faculty of Pharmacy organized the competition to choose the ideal student for the academic year 2022/2023 , in the presence of Prof. Dr. Saudy Mohamed Hassan - Dean of the Faculty of Social Work as an external arbitrator, Prof. Dr. / Hisham Mohamed Tawfik - Professor and Head of the Department of Industrial Pharmacy and Coordinator of Student Activities at the faculty and a Jury Member, Dr. / Mohamed Abdel Jaber Al Wakeel - Assistant Professor in the Department of Pharmaceutical Analytical Chemistry, Social Committee Adviser and Jury Member, and Ms. Omaima Ibrahim Khaled - General Director of Social Activity For trips at the Central Youth Welfare Department and an external arbitrator, where the students applying for the competition made their own presentation: Student / Yara Mahmoud Ahmed - Fourth year, Student / Basmalah Hatem Abdullah - Fourth year, Student / Muhannad Muhammad Khalifa - Fifth year Clinical Pharmacy, Student / Amr Othman Mohamed - the third year, and the student / Ahmed Mohamed Ibrahim - the third year clinical Pharmacy, and all the students were escalated, This was on Tuesday, November 1, 2022, in the Celebration Hall of the Faculty.
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The visit of His Excellency the President of the University and the Vice Presidents of the University to the Faculty of Pharmacy within the activities of (Assiut University - Our Green Future)
Prof. Dr. Ahmed El-Minshawy, the President of the University, visited to inspect the environmental activities inside the faculty (climate changes in the eyes of a pharmacy) as part of a celebration and event – Assiut University (Climate and Our Green Future) accompanied by Prof. Dr. Maha Kamel Ghanem - Vice President University for Community Service and Environmental Development, Prof. Dr. Ahmed Mohamed Abdel Mawla - Vice President for Education and Student Affairs, and Prof. Dr. Thabet Abdel Moneim - Director of the Environmental Studies and Research Center at the university, where they were received by Prof. Dr. Mohamed Mahmoud Abdel Al-Latif - Vice Dean for Community Service and Environmental Development, Prof. Dr. Gihan Nabil Hassan - Vice-Dean for Graduate Studies and Research, and Prof. Dr. Hassan Refaat Hassan - Vice-Dean for Education and Student Affairs, where the attendees praised the distinguished students' participation during the celebration and what they enjoy from Awareness and culture of various environmental issues appeared in their environmental activities and exhibits within the faculty
This was done on Tuesday, November 1, 2022
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Long term high fat diet induces metabolic disorders and aggravates behavioral disorders and cognitive deficits in MAPT P301L transgenic mice
Research Abstract
in the occurrence and development of AD. Given the link between peripheral insulin resistance and tau pathology in streptozotocin-
injected and db/db mouse models of diabetes, we fed high fat diet (HFD) to pR5 mice expressing P301L mutant
human tau, with the aim of developing a new model with characteristics of obesity, T2DM and AD to mimic AD patients
exacerbated by obesity and T2DM, an increasing trend in modern society. In our study, pR5 and C57BL/6 (WT) mice were
randomly allocated to a standard diet (STD) or HFD for 30 weeks starting at 8 weeks of age. Food intake was measured
weekly, body weight and fasting glucose levels were measured fortnightly, and a comprehensive behavioral test battery was
performed to assess anxiety, depression and cognitive dysfunction. Glucose and insulin tolerance tests were performed after
30 weeks of HFD. We also investigated the effect of long term HFD on tau pathology in the brains of WT and P301L mice
by performing western blotting of whole brain homogenates for total tau, phosphorylated tau at Ser396 and Thr231. Our
results show that pR5 mice fed with HFD are more vulnerable to diet induced obesity compared to WT, especially with
increasing age. In addition, pR5 mice on HFD developed glucose intolerance and insulin resistance. It was identified that long
term HFD significantly aggravates depression like behavior and impairs cognitive function in pR5 mice, and also induces
anxiety like behavior in both pR5 and WT mice. Long term HFD was also shown to aggravate tau hyperphosphorylation in
pR5 transgenic mice, and increase total and hyperphosphorylated tau in WT mice. These results indicate that diet induced
obesity of pR5 transgenic mice expressing P301L mutant human tau generates T2DM, and aggravates tau phosphorylation,
and is therefore a model useful for investigations that seek to understand the relationships between AD, T2DM and obesity,
and the underlying biochemical changes and mechanisms associated with metabolic disorders and AD tauopathy.
Research Date
Research Department
Research Journal
Metabolic Brain Disease
Research Member
Research Publisher
Springer US
Research Vol
37
Research Website
https://link.springer.com/article/10.1007/s11011-022-01029-x
Research Year
2022