Background: In the COVID-19 era, social media has a significant benefit in terms of rapid transmission of instructional content. Aim: To evaluate the effect of social media-based nursing instructions on knowledge, and selfhealth monitoring for patients suspected with Covid-19 during quarantine. Setting: Screening unit of Main University Hospital, and Cardiology Hospital at Assiut University Hospitals. Patients: A total of ninety-three patients were chosen by purposive sampling technique. Design: Quasi (Pre–Post-test) experimental study. Tool: A structured interview-based questionnaire contained; Demographic profile, Quarantine patients’ knowledge assessment, & Daily quarantined patient's self-health monitoring. Results: The mean age was 40.86 years old, with the majority being females. There was a highly statistically significant difference between pre/post of total knowledge score regarding Covid-19 and quarantine measures (15.52 ± 6.79, 29.29 ± 2.21) respectively presented by P value equal (0.001**). Furthermore, there was a statistically significant difference between patients' educational level and their pre-total knowledge score with (P-Value = 0.002**). Conclusion: Social media-based nursing instructions could be a useful tool for enhancing knowledge and remote self-health monitoring for patients suspected with Covid-19 while they are at the quarantined period. Recommendations: More researches are needed to see how patients with Covid-19 could be satisfied with social media-based nursing guidance to improve their level of knowledge, as well as remote self-health monitoring.