Background: Vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic (VEXAS) syndrome is recently identified systemic autoinflammatory disease that manifests in adults and has a high morbidity and mortality rate. Aim: to evaluate the effect of implementing an educational program regarding vacuoles, E1-enzyme, X-linked, auto-inflammatory and somatic syndrome on nurses' knowledge in intensive care units. Design: quasi-experimental research design was utilized. Setting: The study was accomplished at the Sohag Main University Hospital, in Critical Care and General ICU. Subjects: Convenient samples of 70 nurses were recruited from general and critical care ICUs Tool I: Structured Interview Questionnaire Assessment Included Nurses’ Demographic Data. Tool II: Nurses’ Knowledge Pre-Post Educational Program Assessment. Results: the mean knowledge score was 7.31±4.1 in the pre-test versus 18 ±1.7 in the post test with high statistically significant difference and about 6% of nurses had satisfactory knowledge level in pretest versus 84% of them after implementation of educational program. Conclusion: After the educational program was put into place, the majority of nurses in the study group had a good level of knowledge, and their overall mean scores significantly improved Recommendation: The current study should be replicated on larger probability samples. Key words: Auto-Inflammatory, Educational Program, E1-Enzyme, Intensive Care Units, Nurses' Knowledge, Somatic Syndrome, Vacuoles, X-Linked.

Between 25 and 40% of extubated patients with traumatic brain injury (TBI) in the intensive care unit at our hospital (Assiut University Hospital–Assiut–Egypt) require reintubation. This reflects the importance of developing better criteria for predicting successful extubation in TBI. We evaluated the accuracy of semi-quantitative cough strength score (SCSS) and Glasgow coma scale (GCS) in predicting extubation outcomes in TBI.

ackground: One of the most common reasons for hospitalization, morbidity, and mortality related to digestive illnesses is Non-variceal upper GIT bleeding. Despite the improvement in the field, management of patients with Non- variceal Upper Gastrointestinal Bleeding (NVUGIB) has become more challenging due to comorbidities and complex therapies. This study aimed to evaluate the effect of implementing nursing care protocol on clinical outcomes of non variceal upper gastrointestinal bleeding patients. Design: A quasi-experimental research design was used. Setting: Gastroenterology Intensive care unit at Sohag University hospital, Upper Egypt. Sample: A convenient sample of 80 adult (male and female) patients was included. Tools: Three tools were utilized to collect data, Too - NVUGIB assessment sheet, Tool II: Nursing NVUGIB care protocol and Tool III: Clinical outcome evaluation tool. Results: Illustrate that most common cause of non-variceal upper GIT bleeding in studied patients was peptic ulcer followed by Gastritis, 50% of study& 45% of control group were using NSAID before coming to hospital. In relation to mortality risk using Rockall score on 1st day of admission about half of study and control group were at high risk for mortality, while at 3rd day 52.5% in study group were at low risk. Conclusion: the implementation of nursing protocol for patients with NVUGIB improves patients' clinical outcomes and decrease rate ofcomplication occurrence. Recommendations: Provide Gastroenterology intensive care unit with clear, illustrative nursing care protocols and booklets for management of patient with Non-variceal upper GIT bleeding. Keywords: Non-variceal upper GIT bleeding, Nursing protocol and clinical outcomes

Background: Thirst and dry mouth are common problem in the intensive care unit (ICU) and these are associated with physical discomfort. Thirst should be treated as thirst persisting is associated with multiple complications Aim of study was to Evaluate the impact of planned nursing care on Patient’s thirst and mouth dryness in the intensive care unit. Research design: A Quasi-experimental study design was used. Setting: the study was conducted in post-operative intensive care unit at Assiut main University Hospital. Subjects: Convenient sample of 60 patients were included in the study and they were assigned randomly to a control group and an intervention group. Four tools were used in this study: I: Patient assessment sheet, II: acute physiology and chronic health evaluation (APACHE II) Score, III: Thirst assessment sheet, IV: Oral Condition Assessment Checklist Results: The Planned nursing care was used had significant reduction of thirst intensity and dry mouth (P<0.01) for study group patients. The results showed that 31% of study group versus 9% of control group had no thirst and 68.4% of study group versus 99.9% of control group had mild thirst in the 5^th day of study Conclusion: Planned nursing care with sterile cold-water spray and lubricating the lips with glycerin lip moisturizer were effective in reducing thirst intensity and mouth dryness. Recommendations: Provide continuous assessment of thirst and mouth dryness. Emphasize on educating nurses about the importance of management of thirst and mouth dryness the intensive care unit through planned nursing intervention

Background: High Flow Nasal Cannula appears to be a promising alternative tostandardoxygen and non-invasive ventilation for treating patients with hypoxemic acute respiratoryfailure. Therefore, the present study aimed to evaluate the effect of high-flow nasal cannula versus noninvasive ventilation on critically ill patient outcomes. Research hypotheses: high-flownasal cannula is expected to be more effective than non-invasive continuous positive airway pressureinreducing the length of stay, mortality rate, and post-extubation complications. Acomparative, Descriptive research design was used. The study was conducted in ICUs of the anesthesiadepartment at Assuit Main University Hospital. A purposive sample of 60 adult male andfemalepatients who were aged (18-60 years) was included in the study and they were assignedintotwogroups (HFNC and NIV). Five tools were used to gather data, I: Patient assessment sheet, II: Glasgow coma scale (GCS), III: Dyspnea Visual Analogue Scale (D-VAS), IV: Device-relateddiscomfort visual analogue scale and V: Clinical outcomes assessment sheet. Results: revealedthat half of the patients in both the HFN and NIV (CPAP) groups stayed in the hospital for 6-10days. Regarding patient progress, there is a statistically significant difference between both groups, withpatients using the HFN protocol showing greater improvement than patients using the CPAPprotocol. Conclusion: The patient in HFN protocol shows improvement in the level of progress thanNIV (CPAP). Recommendations: High-Flow Nasal Cannula may serve as an alternative treatment for hypercapnic respiratory failure, particularly for patients who do not tolerate Non-InvasiveVentilation well. Key words: High Flow Nasal Cannula, Non-invasive ventilation, patient Outcomes

Background: ChatGPT, a language model developed by Open AI, has the potential to play a role in nursing education. This study aims to evaluate effectiveness of ChatGpt as an educational tool for nurses regarding ICU-acquired muscle weakness. Design: A quasi-experimental study design was used. Setting: The study was conducted in general intensive care unit at Sohag main University Hospital. Subjects: Convenient sample of all available nurses working in general ICU. Three tools were used in this study. Tool I: Structured Interview Questionnaire, Part I: Personal and Sociodemographic Data, Part II: Nurses Knowledge Assessment Questionnaire pre &post-test. Tool II: Nurses’ Attitude Assessment Questionnaire: Pré/Post test. Tool III: Feedback from Nurses about ChatGPT Usability and Satisfaction. Results: 77% of the studied nurses had good knowledge versus 23% had inadequate level of knowledge in the Post-test. Also, 72% of the studied nurses revealed satisfied attitude toward using Chat GPT posttest versus 28% of them had unsatisfactory attitude in the post-test. Conclusion: ChatGPT was effective in improving nurses’ knowledge and attitude regarding ICU acquired weakness. Recommendations: Nurses as educators should carefully consider how to integrate ChatGPT into their learning practices.