Abstract
A single dose of zearalenone (10 ~g/g LBW) was injected intraperitoneally to Wistar Albino rats at the age of 50-100 days. The uterine acetyl cholinesterase enzyme was significantly increased in the treated animals compared to that in the controls. Therefore, zearalenone would be considered as an esterogenic effector for increasing the uterine acetyl cholinesterase which enhances uterine relaxation and subsequently improves
its function for pregnancy in prematured-animals. Unlike estradiol, it was interesting to find that the estrogenicity of zearalenone was increased by the moderating progesterone hormone. Moreover, it was revealed in this study that the injected dose of zearalenone
had no deleterious effects on the pregnant rats at 10-12 days period of gestation. The harmful effects of zearalenone on pregnant animals cited in the literature (11, 13, 19) were reviewed.

Abstract
The mathematical analysis for plasma disappearance curve of aflatoxicosed animals, subsequently injected with 45Ca was determined. The analysis showed that the three main compartments of the calcium pool (plasma, bone and the labile calcium pool on the surface of bone and soft tissues) had been affected.Specifically, the fractional rate constant for migration of 45Ca from plasma pool to the labile pool had been diminished to its third value. This led to a corresponding reduction in the calcium content of the bone ash.The probable mechanism by which aflatoxin B r affects calcium dynamics may be interpreted by the inhibitory effect of aflatoxin in the hydroxylation mechanism of vitamin D 3 into an active intermediate. During aflatoxicosis (induction of 15 days) the animals entered a state of calcium deficiency, secondary to intestinal absorption inhibition. This was followed by bone resorption and disturbance of the fractional removal rate constant among different calcium compartments.

A total of 506 isolates of mesophilic, thermophilic and thermotolerant fungi isolated from the poultry feed ingredients included soybean meals, ground maize, cottonseed cake, wheat bran and fish meal, on glucose‐CZAPEK's agar, LITTMAN oxgall agar at 28 °C and yeast starch agar (YPSs) at 45 °C, were screened for their ability to produce hydrolytic protease enzyme on solid media. Most of the fungal isolates were able to produce such enzymes but with variable capabilities. The highest proteolytic activity was exhibited by some isolates of Penicillium chrysogenum, Aspergillus flavus, Thermoascus thermophilus and Rhizopus chizopodifarmis. Of all fungal isolates screened for proteolytic activity, Penicillium chrysogenum and Thermoascus thermophilus produced the highest amounts of proteases. These two isolates were used to study the effect of some environmental and nutritional factors on their proteolytic …

CiNii 論文 - Bradykinin potentiating fraction isolated from venom of Buthus occitanus promotes spermatogenesis in premature mice CiNii 国立情報学研究所 学術情報ナビゲータ[サイニィ ] 日本の論文をさがす 大学図書館の本をさがす 日本の博士論文をさがす 新規登録 ログイン English 検索 すべて 本文あり すべて 本文あり 閉じる タイトル 著者名 著者ID 著者所属 刊行物名 ISSN 巻号 ページ 出版者 参考文献 出版年 年から 年まで 検索 検索 検索 [10/4更新]2022年4月1日からの CiNii ArticlesのCiNii Researchへの統合について Bradykinin potentiating fraction isolated from venom of Buthus occitanus promotes spermatogenesis in premature mice NASSAR AY 被引用 文献: 1件 著者 NASSAR AY 収録刊行物 Rec. Advan. Toxinol. Res. Rec. Advan. Toxinol. Res. 2, 119-135, 1992 被引用文献: 1件中 1-1件を 表示 1 A Scorpion Venom Peptide Fraction Induced Prostaglandin Biosynthesis in Guinea Pig Kidneys : Incorporation of ^<14>C-Linoleic …

The study examines the anti-ulcer activity of Cu(I)-(nicotinic acid)₂Cl [CuCl(HNA)₂]. A dose of 8 mg (23 μmol) of complex/kg body mass was suspended in 0.25% Tween-80 in saline solution and administered intragastrically to male Wistar albino rats which had developed gastric ulcers as a result of pyloric ligation (Shay-rat model). Another group of animals received 5 mg (25 μmol)/kg body mass of the copper-glycinate complex Cu(II)(glycinate)₂ [Cu(II)(Gly)₂]. Both protected as shown by reduction in the ulcer index, inhibition of gastric perforation and death. Significant increases in gastric juice volume and superoxide dismutase (SOD) activity in the gastric mucosa and blood plasma were found with both copper complexes, while the gastric juice prostaglandin E₂ (PGE₂) content was significantly decreased in the Cu(II)(Gly)₂-treated group, it was significantly increased in the gastric mucosa of the CuCl(HNA)₂-treated …

[en] The buthus occitanus, scorpion venom contains a strong bradykinin potentiating factor (BPF) that augments bradykinin effects through enhancing its release. Based on the cytoprotective ability of BPF, the present work investigates it as a radioprotectant. Sublethal whole-body y-irradiation at 1.5 Gy was used. Bone marrow cells suspension (BM cells) alone or in combination with BPF was utilized. Three to four weeks-aged male Guinea pigs were grouped into two major groups. The first was non-irradiated control that was divided into subgroups treated ip with BM cells (2.5 xl06 cells), one dose of BPF (lug/gb wt), BM cells+ BPF, one week spaced two doses of BPF, BM cells+ 2 doses of BPF, one week spaced three doses of BPF or BM cells+ 3 doses of BPF. Second major group (irradiated group) at 1.5 Gy that, subdivided and treated similarly. 5 animals from each group were killed at 7, 14 and 21 days from the initiation of treatment (3 h after irradiation). The subgroups of non-irradiated animals showed an increase in spleen wt and colony formation, thymus population, and globulins content particularly in those subgroups that stayed for the later time periods (14 and 21 days) and that treated with combined BM cells+ BPF or that groups that were treated with two or three BPF doses. Irradiation caused dramatic destruction in thymus and the spleen reflected on reduction of the lower globulins content. Treatment with BM cells, BM cells+ double doses of BPF or triple doses of BPF caused complete recovery in all measured indices, the best result was observed in those of subgroups treated with BM cells+ double doses of BPF or treated with triple …

ABSTRACT
Cisplatin (CP) is considered as a major antineoplastic drug against a broad spectrum of malignancies. CP acts on cancer cells by releasing free radicals which at the same time damage liver and kidney cells. The tissue specific toxicity of cisplatin to the kidneys is well documented. However, at higher doses less common toxic effects such as hepatotoxicity may arise. Strategies to protect tissues against CP toxicity are of clinical interest. In this study, we aimed to investigate the hepatotoxicity of CP which it may be mediated by oxidative stress and to establish whether some antioxidants, namely vitamin C, N,NDiphenyl- X-phenylenediamine (DPPD) and L-cystiene, may provide protection against CP hepatotoxicity. Forty adult male albino rats (1 20-1 50 g) were divided into 5 groups (8 rats each). CP was injected once a week (2 mg/kg) for four weeks. The antioxidants DPPD (1 25 mg/kg b.w. ), vitamin C (1 00 mg/kg) and L-cystiene (1 00 mg/kg) were also injected once a week 24 hour prior to CP injection. The control group
was injected with saline. All doses were injected intraperitoneally. Rats of different groups were killed by cervical dislocation, 24 hours after the last injection and blood was collected into a sterilized tube containing EDTA to separate plasma. The livers was taken for histological and biochemical examinations. CP-induced oxidative stress was indicated by increased level of LPO and superoxide anion in hepatic tissue and plasma. Also, CP induced decline of antioxidant enzymes such as SOD, CAT, GST and GGT and a decreased level of GSH, Vit. C and Vit. E in hepatic tissue and plasma. Treatment with Vit. C, DPPD and L-cysteine in combination with CP restored LPO and superoxide anion,
the activities of SOD, GST, CAT and GGT and the content of GSH, Vit. C and Vit. E to about normal control levels. in conclusion treatment with Vit. C, DPPD or L-cysteine in combination with CP may be effective to protect from oxidative hepatic injury that induced by CP treatment.