Plasma high density lipoprotein (HDL)-cholesterol and/or apo A-I levels appear to be inversely related to the occurrence of acute myocardial infarctions and have an impact on the onset and progress of atherosclerosis.1,2 Since the outer surface of the high density lipoprotein particle has a low cholesterol/phosphatidylcholine ratio in comparison to most of the cell membranes,3 it is suggested to be an effective acceptor for the transport of cholesterol to various tissues. HDL facilitates the removal of the peripheral tissue cholesterol and delivers it within the “reverse cholesterol transport” to the liver.4 A recent investigation5 on the scavenger function of sinusoidal liver cells showed that chemically acetylated HDL underwent receptor-mediated endocytosis through a pathway distinct from acetylated low-density lipoprotein (LDL) or formaldehyde-treated serum albumin, which suggests the presence of a scavenger …

In vivo and in vitro effects of copper(I)nicotinic acid complexes on lipids and lipoproteins. - Abstract - Europe PMC Sign in | Create an account https://orcid.org Europe PMC Menu About Tools Developers Help Contact us Helpdesk Feedback Twitter Blog Tech blog Developer Forum Europe PMC plus Search life-sciences literature (Over 39 million articles, preprints and more) Search Advanced search This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our privacy notice and cookie policy. Abstract Citations & impact In vivo and in vitro effects of copper(I)nicotinic acid complexes on lipids and lipoproteins

The emergence of multi-drug resistant (MDR) strains and even pan drug resistant (PDR) strains is alarming. In this study, we studied the resistance pattern of E. coli pathogens recovered from patients with different infections in different hospitals in Minia, Egypt and the co-existence of different resistance determinants. E. coli was the most prevalent among patients suffering from urinary tract infections (62%), while they were the least isolated from eye infections (10%). High prevalence of MDR isolates was found (73%) associated with high ESBLs and MBLs production (89.4% and 64.8%, respectively). bla_TEM (80%) and bla_NDM (43%) were the most frequent ESBL and MBL, respectively. None of the isolates harbored bla_KPC and bla_OXA-48 carbapenemase like genes. Also, the fluoroquinolone modifying enzyme gene aac-(6′)-Ib-cr was detected in 25.2% of the isolates. More than one gene was found in 81% of the isolates. Azithromycin was one of the most effective antibiotics against MDR E. coli pathogens. The high MAR index of the isolates and the high prevalence of resistance genes, indicates an important public health concern and high-risk communities where antibiotics are abused.