The intricate dynamics of odorants in the indoor environment and human respiratory system remain poorly understood. In the present study, we integrate odor sensory tests (OSTs) and computational fluid dynamics coupled with a physiologically based pharmacokinetic (CFD-PBPK) model to elucidate various aspects of odorant transport and olfaction dynamics. Safe yogurt-derived substances were incorporated into OSTs to prevent harmful exposure. Acetaldehyde was identified as a key active component in determining odor intensity, prompting further analysis of acetone and other four constituents. Logarithmic correlations were established between the perceived odor intensity from the OSTs and both time-averaged absorption flux and equilibrium concentration within the olfactory mucus layer. These parameters were numerically captured, enabling the logarithmic approximation of odor intensity for different breathing profiles and developing reliable prediction models for odor sensation in the indoor environment based on quantifiable physiological parameters. Location-specific analysis revealed the nostrils and olfactory regions as the most accurate indicators of perceived odor intensity, proving the limitations of rough sensory assessments in the indoor/breathing zone scales. This study offers insights for potential safe and sustainable applications, such as smart odor displays, e-noses, and sensors/control systems in the indoor environment, particularly for long-term exposure in industries that emit harmful compounds.