The effects of climate change pose significant threats to ecosystems, biodiversity, and the well-being of human populations. Aim: The study aimed to explore the relation between climate changes, quality of life and psychological status among Assiut city population. Setting: The study was conducted at Assiut city by utilizing web-based online survey. The study sample was 1300 as a convenience sample. Five tools were used; the socio-demographic data, Climate Change Anxiety Scale, Climate Change Worry Scale, Self- Efficacy Scale and the WHOQOL-BREF questionnaire. Results: There was strong positive correlation between climate change worry and climate change anxiety Scales (r value .838). Moreover, there was also positive correlation between self-efficacy, climate change worry and climate change anxiety scales (r value, .088, .174) respectively. Conclusions & Recommendation: The research outcomes revealed a substantial association between anxiety and worry levels and socio-demographic factors. Furthermore, the study demonstrated a noteworthy correlation between socio-demographic characteristics and overall quality of life which significantly impact individuals' well-being in relation to climate change-induced anxiety and worry. Implementing an educational program on climate change among the population through mass media as a strategy to address the challenges posed by climate change.