Ascites is a condition of pathologic fluid collection within the abdominal cavity. The aim was to evaluate the impact of designing nursing instructions on knowledge and activity of daily living for cirrhotic patients with ascites.

Quasi experimental (Pre / post-test).

Tropical Medicine and Gastroenterology Department of Al-Rajhi Liver Hospital.

A purposive sample of sixty male and female adult patients diagnosed with ascites due to liver cirrhosis.

Tool (I): A structured interview questionnaire. Tool (II): Activity of daily living scale.

A statistically significant difference between pre, post 3 month and 6 month of implementing the designing nursing instruction regarding patient’s knowledge and activity of daily living with p-value <0.01.

A great improvement in patient’s knowledge and independently in performing activity of daily living post the implementation of the designing nursing instructions than pre assessment.

Patients should be provided with sufficient relevant written information to remind them about what they can do to cope with their disease