Background: Stroke is a major cause of disability in adults and elderly. Chronic
complications arising from this disease have impact on the affected patients' reduced selfefficacy. Aim: Evaluate the effectiveness of caregiver training program on stroke patient's self-efficacy. Quasi-experimental design was utilized. Setting: The study conducted in the departments and outpatient clinics of neuropsychiatric diseases and neurosurgery hospital at Assiut University Hospitals. Sample: Caregivers and their patients admitted to neuropsychiatric diseases and neurosurgery hospital, during 6 months (equal number of 125 for both). Tools: Include four tools. Tool 1 structured interview questionnaires. Tool II: Caregivers’ knowledge about stroke. Tool III: Caregivers' practices regarding stroke patients' care. Tool IV: Stroke Self-Efficacy Questionnaire (SSEQ). Results: 95.2% of caregiver's have unsatisfactory knowledge about stroke in pre-program, compared to 84.8% and 76.0% have satisfactory knowledge at post program and follow up; respectively. Also, caregiver practices levels of patient's care were 100% inadequate in pre-program. These levels improved to adequate practice in post program and follow up (72.0% & 75.2%); respectively. A statistically significant difference of stroke patient's self-efficacy through training program p =0.000. Conclusion: A caregivers training had a positive effect on stroke patient's self‐efficacy. Recommendations: Continues caregivers training regarding care of stroke patients.