Ulcerative colitis (UC) refers to a disease in which the lining of the colon becomes inflamed. In patients . with ulcerative colitis, the immune system inappropriately targets the lining of the colon. Most cases (Ire treated at home, which points to the importance of self-care in its management. This study aim was to determine the effect of an educational program on ulcerative colitis patients' knowledge and self-care practices. To conduct tit is study a sample of sixty in patients with ulcerative colitis was selected from the tropical medicine department in Assiut university hospital. They were divided into two equal study and the control groups. The study group received an educational program. Data were collected using a patient assessment interview sheet. Pre-post comparisons of patients' knowledge and practice showed statistically significant improvements in the study group but not in the control groups, p