In vivo and in vitro effects of copper(I)nicotinic acid complexes on lipids and lipoproteins. - Abstract - Europe PMC Sign in | Create an account https://orcid.org Europe PMC Menu About Tools Developers Help Contact us Helpdesk Feedback Twitter Blog Tech blog Developer Forum Europe PMC plus Search life-sciences literature (Over 39 million articles, preprints and more) Search Advanced search This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our privacy notice and cookie policy. Abstract Citations & impact In vivo and in vitro effects of copper(I)nicotinic acid complexes on lipids and lipoproteins

The emergence of multi-drug resistant (MDR) strains and even pan drug resistant (PDR) strains is alarming. In this study, we studied the resistance pattern of E. coli pathogens recovered from patients with different infections in different hospitals in Minia, Egypt and the co-existence of different resistance determinants. E. coli was the most prevalent among patients suffering from urinary tract infections (62%), while they were the least isolated from eye infections (10%). High prevalence of MDR isolates was found (73%) associated with high ESBLs and MBLs production (89.4% and 64.8%, respectively). bla_TEM (80%) and bla_NDM (43%) were the most frequent ESBL and MBL, respectively. None of the isolates harbored bla_KPC and bla_OXA-48 carbapenemase like genes. Also, the fluoroquinolone modifying enzyme gene aac-(6′)-Ib-cr was detected in 25.2% of the isolates. More than one gene was found in 81% of the isolates. Azithromycin was one of the most effective antibiotics against MDR E. coli pathogens. The high MAR index of the isolates and the high prevalence of resistance genes, indicates an important public health concern and high-risk communities where antibiotics are abused.

Abstract
A single dose of zearalenone (10 ~g/g LBW) was injected intraperitoneally to Wistar Albino rats at the age of 50-100 days. The uterine acetyl cholinesterase enzyme was significantly increased in the treated animals compared to that in the controls. Therefore, zearalenone would be considered as an esterogenic effector for increasing the uterine acetyl cholinesterase which enhances uterine relaxation and subsequently improves
its function for pregnancy in prematured-animals. Unlike estradiol, it was interesting to find that the estrogenicity of zearalenone was increased by the moderating progesterone hormone. Moreover, it was revealed in this study that the injected dose of zearalenone
had no deleterious effects on the pregnant rats at 10-12 days period of gestation. The harmful effects of zearalenone on pregnant animals cited in the literature (11, 13, 19) were reviewed.

Abstract
The mathematical analysis for plasma disappearance curve of aflatoxicosed animals, subsequently injected with 45Ca was determined. The analysis showed that the three main compartments of the calcium pool (plasma, bone and the labile calcium pool on the surface of bone and soft tissues) had been affected.Specifically, the fractional rate constant for migration of 45Ca from plasma pool to the labile pool had been diminished to its third value. This led to a corresponding reduction in the calcium content of the bone ash.The probable mechanism by which aflatoxin B r affects calcium dynamics may be interpreted by the inhibitory effect of aflatoxin in the hydroxylation mechanism of vitamin D 3 into an active intermediate. During aflatoxicosis (induction of 15 days) the animals entered a state of calcium deficiency, secondary to intestinal absorption inhibition. This was followed by bone resorption and disturbance of the fractional removal rate constant among different calcium compartments.