ABSTRACT
Mycotoxins are secondary metabolites produced by Aspergillus, Penicillium and other genera which contaminate food and exhibit hazardous effects on humans and animals. Aflatoxins (AFs) caused liver necrosis, fibrosis. In the present study, we planned to evaluate the action of bradykinin potentiating factor (BPF) extracted from Egyptian cobra snake venom and synthetic antioxidants; butylated hydroxytoluene (BHT) and oltipraz (OPZ) on the hepatic tissue of aflatoxicosed rats. Aflatoxicosis caused a significant increase of nitric oxide (NO) and lipid peroxidation as malondialdehyde (MDA) associated with a significant decrease in the level of total thiols, glutathione (GSH), and the activities of glutathione peroxidase (GPx) and transferase (GST). In addition to a decrease in the counts of white blood cells (WBCs), lymphocytes (LYM), monocytes (MONO), eosinophils (EOS), red blood cells (RBCs) and an increase in neutrophil counts (NEUT) as well as a significant decrease in the gene expression of hepatic interleukin-1β (Il-1β). The previous changes were confirmed by histopathological alterations. Treatment of aflatoxicosed rats with any of BPF, BHT or OPZ resulted in amelioration of the oxidative stress parameters, blood picture and hepatic IL-1β with improvement in histological features. In conclusion, either BPF, BHT or OPZ can be used for the treatment of aflatoxicosis.
عن مراحل الانعاش الوريدى حاضر فيها كل من :
حيث تناول ا.د/ جمال حسن شرح مقدمة عن الدورة وأهدافها.والدكتور/ محمود قطب محاضرة عن أجهزة تدفق الأكسجين .عن التشريح الأساسي والفيزيولوجي للممرات الهوائية للأطفال إدارة بسيطة للممرات الهوائية محاضرة الدكتور/ ضياء تامر لشرح الادارة المتقدمة والجراحية للممرات الهوائية و تركيب الأنابيب الحنجرية .كما تضمن اليوم تدريبا عمليا عن تدفق الأكسجين والادارة البسيطة للممرات الهوائية والإدارة المتقدمة والجراحية .
Award 2022
Plasma high density lipoprotein (HDL)-cholesterol and/or apo A-I levels appear to be inversely related to the occurrence of acute myocardial infarctions and have an impact on the onset and progress of atherosclerosis.1,2 Since the outer surface of the high density lipoprotein particle has a low cholesterol/phosphatidylcholine ratio in comparison to most of the cell membranes,3 it is suggested to be an effective acceptor for the transport of cholesterol to various tissues. HDL facilitates the removal of the peripheral tissue cholesterol and delivers it within the “reverse cholesterol transport” to the liver.4 A recent investigation5 on the scavenger function of sinusoidal liver cells showed that chemically acetylated HDL underwent receptor-mediated endocytosis through a pathway distinct from acetylated low-density lipoprotein (LDL) or formaldehyde-treated serum albumin, which suggests the presence of a scavenger …
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