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Efficacy of intraoperative use of tranexamic acid in reducing blood loss from telescoping nail application in osteogenesis imperfecta. A randomized controlled trial

Research Abstract
Background
Osteogenesis imperfecta (O.I) is a rare disease caused by an abnormality in type 1 collagen synthesis leading to repeated fractures after low-energy trauma and progressive long bones deformity. Telescoping nail application and surgical correction of these deformities usually necessitates multiple osteotomies and significant bleeding occur due to weakened capillaries and impaired platelet activity. Tranexamic acid (TXA) has an antifibrinolytic effect which is useful in reducing bleeding and need for blood transfusions following several orthopaedic procedures.
Hypothesis
The use of intraoperative (Local and Intravenous) tranexamic acid reduces blood loss during femoral telescoping nail application in O.I. patients.
Material and methods
A prospective randomized controlled study was carried out on 40 patients during applying femoral telescoping nail divided into Group A: (case TXA); 20 patients receiving …
Research Authors
Hesham Mohamed Elbaseet Abdelghani
Research Date
Research Image
Efficacy of intraoperative use of tranexamic acid in reducing blood loss from telescoping nail application in osteogenesis imperfecta. A randomized controlled trial
Research Journal
Orthopaedics & Traumatology: Surgery & Research
Research Pages
5
Research Publisher
Elsevier B.V.
Research Rank
Q1
Research Vol
In Press, Corrected Proof
Research Website
https://www.sciencedirect.com/science/article/abs/pii/S1877056824001749
Research Year
2024

U-shaped hip capsular incision: An easier way to do hip capsulorrhaphy in developmental dysplasia of the hip–Technical note

Research Abstract

Developmental dysplasia of the hip (DDH) is one of the most common hip anomalies encountered in pediatric patients. Stabilization of the femoral head into the acetabulum is crucial for normal hip joint development. When surgical intervention is decided, open reduction is needed to remove any obstacle that hinders hip reduction. Capsulorraphy is an essential step for minimizing instability of the hip after reduction. The classic T-shaped capsular incision is done by two incisions: vertical limb parallel to femoral neck axis and a transverse one parallel to the inguinal ligament 5 mm distally to proximal capsular attachment. The cumbersomeness of this technique was noticed in suturing of the resulted two flabs from this incision. So, the suggested U-shaped incision makes suturing of the capsule easier with multiple stitches.

Research Authors
Hesham Mohamed Elbaseet, Mohamed Abdelhady Abdelzaher
Research Date
Research Image
U-shaped hip capsular incision: An easier way to do hip capsulorrhaphy in developmental dysplasia of the hip–Technical note
Research Journal
Orthopaedics & Traumatology: Surgery & Research
Research Pages
5
Research Publisher
Elsevier B.V.
Research Rank
Q1
Research Vol
Volume 110, Issue 4
Research Website
https://www.sciencedirect.com/science/article/abs/pii/S1877056823001081
Research Year
2024

Outcomes after surgery for children in Africa (ASOS-Paeds): a 14-day prospective observational cohort study

Research Abstract

Summary

Background

Safe anaesthesia and surgery are a public health imperative. There are few data describing outcomes for children undergoing anaesthesia and surgery in Africa. We aimed to get robust epidemiological data to describe patient care and outcomes for children undergoing anaesthesia and surgery in hospitals in Africa.

Methods

This study was a 14-day, international, prospective, observational cohort study of children (aged <18 years) undergoing surgery in Africa. We recruited as many hospitals as possible across all levels of care (first, second, and third) providing surgical treatment. Each hospital recruited all eligible children for a 14-day period commencing on the date chosen by each participating hospital within the study recruitment period from Jan 15 to Dec 23, 2022. Data were collected prospectively for consecutive patients on paper case record forms. The primary outcome was in-hospital postoperative complications within 30 days of surgery and the secondary outcome was in-hospital mortality within 30 days after surgery. We also collected hospital-level data describing equipment, facilities, and protocols available. This study is registered with ClinicalTrials.gov, NCT05061407.

Findings

We recruited 8625 children from 249 hospitals in 31 African countries. The mean age was 6·1 (SD 4·9) years, with 5675 (66·0%) of 8600 children being male. Most children (6110 [71·2%] of 8579 patients) were from category 1 of the American Society of Anesthesiologists Physical Status score undergoing elective surgery (5325 [61·9%] of 8604 patients). Postoperative complications occurred in 1532 (18·0%) of 8515 children, predominated by infections (971 [11·4%] of 8538 children). Deaths occurred in 199 (2·3%) of 8596 patients, 169 (84·9%) of 199 patients following emergency surgeries. Deaths following postoperative complications occurred in 166 (10·8%) of 1530 complications. Operating rooms were reported as safe for anaesthesia and surgery for neonates (121 [54·3%] of 223 hospitals), infants (147 [65·9%] of 223 hospitals), and children younger than 6 years (188 [84·3%] of 223 hospitals).

Interpretation

Outcomes following anaesthesia and surgery for children in Africa are poor, with complication rates up to four-fold higher (18% vs 4·4–14%) and mortality rates 11-fold higher than high-income countries in a crude, unadjusted comparison (23·15 deaths vs 2·18 deaths per 1000 children). To improve surgical outcomes for children in Africa, we need health system strengthening, provision of safe environments for anaesthesia and surgery, and strategies to address the high rate of failure to rescue.

Funding

Jan Pretorius Research Fund of the South African Society of Anaesthesiologists and Association of Anesthesiologists of Uganda.
Research Authors
Hesham Mohamed Elbaseet Abdelghani
Research Date
Research Image
Outcomes after surgery for children in Africa ASOS-Paeds a 14-day prospective observational cohort study
Research Journal
lancet
Research Pages
30
Research Publisher
Elsevier B.V.
Research Rank
Q1
Research Vol
Volume 403, Issue 10435
Research Website
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)00103-X/abstract
Research Year
2024

Analysis of the association between the Slit2 biomarker and systemic lupus erythematosus

Research Abstract
To assess the association between various systemic lupus erythematosus (SLE) disease manifestations, SLE disease activity index 2000 (SLEDAI-2K), systemic lupus international collaborating clinics/American College of Rheumatology Damage Index (SLICC/ACR- SDI) and serum levels of Slit2 in SLE patients.
Research Authors
ايمان صفوت محمد حسانين
Research Date
Research Member

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List of approved hours for doctors who have been registered for the master’s degree on the new list in October 2024

List of approved hours for doctors who have been registered for the master’s degree on the new list in October 2024

Posterolateral Fusion Versus Posterior Lumbar Interbody Fusion for Adult Low-Grade Isthmic Spondylolisthesis: Analysis of Sagittal Radiographic Parameters - A Randomized Controlled Trial

Research Abstract

Study Design

Randomized controlled trial.

Objectives

To compare the effect of posterolateral fusion (PLF) and posterior lumbar interbody fusion (PLIF) on sagittal radiographic parameters in patients with low-grade isthmic spondylolisthesis. Additionally, to explore the correlation between changes in these parameters and clinical outcomes.

Methods

Forty-six consecutive patients with single-level low-grade isthmic spondylolisthesis were initially enrolled. They were randomly assigned to undergo either PLF or PLIF. Patients were followed up for at least 24 months. Radiographic outcomes included pelvic incidence, pelvic tilt, sacral slope, lumbar lordosis, sagittal vertical axis, T1 pelvic angle, slip angle, slip degree and disc height. Clinical outcomes were assessed by the Oswestry Disability Index (ODI) and visual analogue scale (VAS).

Results

Four participants were lost to follow-up. Of the remaining 42 patients, 29 were …

Research Authors
Mahmoud Fouad Ibrahim, Fady Samy Saeed, Essam Mohammed El-Morshidy, Khaled Mohammed Hassan, Mohamed Gamal Hassan, Mohammad El-Sharkawi, Belal Elnady
Research Date
Research Journal
Global Spine Journal
Research Pages
21925682241254317
Research Publisher
SAGE Publications
Research Website
https://journals.sagepub.com/doi/full/10.1177/21925682241254317
Research Year
2024

Validation of the AO Spine CROST (Clinician Reported Outcome Spine Trauma) in the clinical setting

Research Abstract

Purpose

To evaluate feasibility, internal consistency, inter-rater reliability, and prospective validity of AO Spine CROST (Clinician Reported Outcome Spine Trauma) in the clinical setting.

Methods

Patients were included from four trauma centers. Two surgeons with substantial amount of experience in spine trauma care were included from each center. Two separate questionnaires were administered at baseline, 6-months and 1-year: one to surgeons (mainly CROST) and another to patients (AO Spine PROST—Patient Reported Outcome Spine Trauma). Descriptive statistics were used to analyze patient characteristics and feasibility, Cronbach’s α for internal consistency. Inter-rater reliability through exact agreement, Kappa statistics and Intraclass Correlation Coefficient (ICC). Prospective analysis, and relationships between CROST and PROST were explored through descriptive statistics and Spearman correlations …

Research Authors
Said Sadiqi, Erin EA de Gendt, Sander PJ Muijs, Marcel WM Post, Lorin M Benneker, Martin Holas, Jin W Tee, Christoph E Albers, Sonja Häckel, Juraj Svac, Richard J Bransford, Mohammad M El-Sharkawi, Frank Kandziora, Shanmuganathan Rajasekaran, Klaus J Schn
Research Date
Research Journal
European spine journal
Research Publisher
Springer Berlin Heidelberg
Research Website
https://link.springer.com/article/10.1007/s00586-024-08145-5
Research Year
2024

AO Spine Guideline for the Use of Osteobiologics (AOGO) in Anterior Cervical Discectomy and Fusion for Spinal Degenerative Cases

Research Abstract

Study design

Guideline

Objectives

To develop an international guideline (AOGO) about the use of osteobiologics in anterior cervical discectomy and fusion (ACDF) for treating degenerative spine conditions.

Methods

The guideline development process was guided by AO Spine Knowledge Forum Degenerative (KF Degen) and followed the Guideline International Network McMaster Guideline Development Checklist. The process involved 73 participants with expertise in degenerative spine diseases and surgery from 22 countries. Fifteen systematic reviews were conducted addressing respective key topics and evidence was collected. The methodologist compiled the evidence into GRADE Evidence-to-Decision frameworks. Guideline panel members judged the outcomes and other criteria and made the final recommendations through consensus.

Results

Five conditional recommendations were created. A conditional …

Research Authors
Hans Jörg Meisel, Amit Jain, Yabin Wu, Christopher T Martin, Juan Pablo Cabrera, Sathish Muthu, Waeel O Hamouda, Ricardo Rodrigues-Pinto, Jacobus J Arts, Arun-Kumar Viswanadha, Gianluca Vadalà, Pieter-Paul A Vergroesen, Stipe Ćorluka, Patrick C Hsieh, And
Research Date
Research Journal
Global Spine Journal
Research Pages
6-13
Research Publisher
SAGE Publications
Research Website
https://journals.sagepub.com/doi/full/10.1177/21925682231178204
Research Year
2024

Do Osteobiologics Augment Fusion in Anterior Cervical Discectomy and Fusion Surgery Performed With Mechanical Interbody Devices (Polyether ether ketone, Carbon Fiber, Metal …

Research Abstract

Study design

Systematic Review of the Literature.

Objective

The purpose of this study was to perform a systematic review describing fusion rates for anterior cervical discectomy and fusion (ACDF) using autograft vs various interbody devices augmented with different osteobiologic materials.

Methods

A systematic review limited to the English language was performed in Medline, Embase and Cochrane library using Medical Subject Heading (MeSH) terms. Studies that evaluated fusion after ACDF using autografts and osteobiologics combined with PEEK, carbon fibre, or metal cages were searched for. Articles in full text that met the criteria were included in the review. The main outcomes evaluated were the time taken to merge, the definition of the fusion assessment, and the modality of the fusion assessment. The risk of bias of each article was assessed by the MINORS score or ROB 2.0 depending on the randomisation …

Research Authors
Viswanadha Arun-Kumar, Stipe Corluka, Zorica Buser, Yabin Wu, Mohammad El-Sharkawi, Charles André Carazzo, Nikhil Ponugoti, Jeffrey C Wang, Hans Jörg Meisel, AO Spine Knowledge Forum Degenerative
Research Date
Research Journal
Global Spine Journal
Research Pages
24-33
Research Publisher
SAGE Publications
Research Website
https://journals.sagepub.com/doi/full/10.1177/21925682231188626
Research Year
2024
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