The clinical manifestations, blood picture, blood chemistry and patho-morphological changes are reported in dogs with experimental intestinal obstruction of the duodenum or the ileum. Body temperature and pulse rate revealed a moderate increase. The most obvious clinical signs were abdominal pain, depression, vomiting, dehydration, shivering and ataxia, followed by collapse, coma and death. Haemoconcentration and leucocytosis were manifested by the increased values of R.B. Cs., HB., P.C.V., M.C.H.C. and leucocytes. M.C.V. show¬ed a slight fall while M.C.H. showed a slight change. There was a marked neutrophilia with a decrease in the number of the other types of leucocytes. Variations in the level of serum electrolytes occurred throughout the survival period of the animals. There was a progressive hypoglycaemia throughout the post-operative days in both groups. At first, the level of total serum proteins increased and then finally it declined until death. A marked increase was found in the values of N.P.N.,B.U.N., blood creatinine and serum indican in both groups. Marked toxaemic lesions were seen postmortem.

A method of auxiliary liver homotransplantation in dogs is described. The experiments, which are of a preliminary nature, were done on 12 dogs of the native breed which received grafts from small donors of the same breed, sex and blood group. The idea included the replacement of the graft at the site of the spleen, with anastomosis of the graft's vena cava, portal vein and aorta to the recipient's left renal vein, splenic vein and splenic artery, respectively. The method proved to be technically satisfactory. Survival times up to76 hours were obtained. Taking into consideration the results obtained from the pathological observations and the probable causes of death in the dogs and with the use of improved immunosuppressive regimes, we hope to obtain better results in future experiments.