Synthesis of Some New Benzoxazole, Benzthiazole and Benzimidazole Derivatives with Expected Biological Activity

Research Authors
H.A. El-sherief, A.M. Mahmoud, A.E. Abdel-Rahman and G.M. El-Naggar
Research Department
Department of chemistry
Research Journal
1- Presented, inpart, at the XVII Egyptian conference of Pharm. Sc., Cairo, Egypt Feb. 22, (1982) & 2- J. Indian Chem. Soc.,
Research Member
Hasan Ahmed Hasan Ahmed El-sheref
Research Pages
pp. 58-60
Research Rank
2
Research Vol
Vol. 60,
Research Year
1983

Synthesis of Some New Benzoxazole, Benzthiazole and Benzimidazole Derivatives with Expected Biological Activity

Research Authors
H.A. El-sherief, A.M. Mahmoud, A.E. Abdel-Rahman and G.M. El-Naggar
Research Department
Department of chemistry
Research Journal
1- Presented, inpart, at the XVII Egyptian conference of Pharm. Sc., Cairo, Egypt Feb. 22, (1982) & 2- J. Indian Chem. Soc.,
Research Member
Galal Mostafa ahmed Mousa El-nagar
Research Pages
pp. 58-60
Research Rank
2
Research Vol
Vol. 60,
Research Year
1983

Synthesis and Biological Activity of some New Benzimidazolylazetidin-2-one and –Thiazolidin-4-ones

Research Abstract
Arylidene-2-aminobenzimidazoles (1) were prepared by condensation of 2-aminobenzimidazole with aromatic aldehydes. Cyclocondensation of mercaptoacetic acid, chloracetylchloride and phthaloyl glycyl chloride on 1 giving the corresponding 4-thiazolidinones (2) and azetidinones (3 and 4) respectively, in good yields. The biological activities of the prepared compounds were screened against several strains of bacteria.
Research Authors
A.E. Abdel-Rahman, A.M. Mahmoud, G.M. El-Naggar and H.A. El-Sherief
Research Department
Department of chemistry
Research Journal
Bull. Fac. Sci., Assuit Univ. 11(1)B p-p. 48 (1982). & Pharmazie
Research Member
Hasan Ahmed Hasan Ahmed El-sheref
Research Pages
pp. 589-590
Research Rank
2
Research Vol
Vol. 38, No. 9
Research Year
1983

Synthesis and Biological Activity of some New Benzimidazolylazetidin-2-one and –Thiazolidin-4-ones

Research Abstract
Arylidene-2-aminobenzimidazoles (1) were prepared by condensation of 2-aminobenzimidazole with aromatic aldehydes. Cyclocondensation of mercaptoacetic acid, chloracetylchloride and phthaloyl glycyl chloride on 1 giving the corresponding 4-thiazolidinones (2) and azetidinones (3 and 4) respectively, in good yields. The biological activities of the prepared compounds were screened against several strains of bacteria.
Research Authors
A.E. Abdel-Rahman, A.M. Mahmoud, G.M. El-Naggar and H.A. El-Sherief
Research Department
Department of chemistry
Research Journal
Bull. Fac. Sci., Assuit Univ. 11(1)B p-p. 48 (1982). & Pharmazie
Research Member
Galal Mostafa ahmed Mousa El-nagar
Research Pages
pp. 589-590
Research Rank
2
Research Vol
Vol. 38, No. 9
Research Year
1983

Synthesis and spectra of thiazoloaminoquinones and heterocyclic quinones containing both Imidazole and thiazole Nuclei

Research Authors
I.M. Issa, A.A. El-Samahy, R.N. Issa, G.M. El-Naggar, and H.S. El-Kashief
Research Department
Department of chemistry
Research Journal
1-Presented, in part, at the 4th pan-Arab Congress of pharm.Sc., Cairo Egypt.Oct. 29, (1974). & Indian J. Chem
Research Member
Hussein Mohamed salama El-kashef
Research Rank
3
Research Vol
Vol. 15,
Research Year
1977

Synthesis and spectra of thiazoloaminoquinones and heterocyclic quinones containing both Imidazole and thiazole Nuclei

Research Authors
I.M. Issa, A.A. El-Samahy, R.N. Issa, G.M. El-Naggar, and H.S. El-Kashief
Research Department
Department of chemistry
Research Journal
1-Presented, in part, at the 4th pan-Arab Congress of pharm.Sc., Cairo Egypt.Oct. 29, (1974). & Indian J. Chem
Research Member
Galal Mostafa ahmed Mousa El-nagar
Research Rank
3
Research Vol
Vol. 15,
Research Year
1977

Isomeric conversion of the oxides of α–(cinnamyl)-p-substituted benzoylacetic acid esters to 4,5-dihydrofuran

Research Authors
G.M. El-Naggar and M.A. El-Dawy
Research Department
Department of chemistry
Research Journal
Presented, in part, at the 4th Pan-Arab-Congress of Pharm. Sci., Cairo, Egypt Oct. 29, (1974). & Indian J. Chem
Research Member
Galal Mostafa ahmed Mousa El-nagar
Research Rank
2
Research Vol
Vol. 14,
Research Year
1976

Studies on the Reaction of N-(3-Carbethoxy-4,5,7-tetrahydrobenzo(b)thien-2-yl)-N’-phenylthiourea with Hydrazine Hydrate

Research Abstract
The reaction of N-(3-carbethoxy-4,5,6,7-tetrahydrobenzo[b]thien-2-yl)-N-phenylthiourea (1) with hydrazine hydrate in 1-butanol afforded a mixture of compounds 2, 3 and 4. Treatment of 3 and 4 with nitrous acid gave 6 and 8 respectively, while reactions of 3 with acetylacetone gave 7. Synthesis of tetracyclic compounds 9a-f and 11 from the reactions of 3 with ethyl orthoformate or appropriate acids, acid chloride, carbon disulphide and/or ethyl chloroformate. Also its reaction with isothiocyanate derivatives gave the corresponding thiosemicarbzides 12a,b which on, refluxing in alcoholic KOH gave the unexpected tetracyclic products 14a,b. Similarly the tetracyclic compounds 16a-e and 19 were obtained by cyclization of 4 and 18 respectively.
Research Authors
El-Sherief Hassan A.H., El-Naggar Galal M., Hozien Zeinab A., Ei-Sawaisi Suliman M
Research Department
Department of chemistry
Research Journal
Journal of Heterocyclic Chemistry
Research Member
Hasan Ahmed Hasan Ahmed El-sheref
Research Pages
pp. 467 – 474
Research Rank
2
Research Vol
Vol. 45, No. 2
Research Year
2008

Studies on the Reaction of N-(3-Carbethoxy-4,5,7-tetrahydrobenzo(b)thien-2-yl)-N’-phenylthiourea with Hydrazine Hydrate

Research Abstract
The reaction of N-(3-carbethoxy-4,5,6,7-tetrahydrobenzo[b]thien-2-yl)-N-phenylthiourea (1) with hydrazine hydrate in 1-butanol afforded a mixture of compounds 2, 3 and 4. Treatment of 3 and 4 with nitrous acid gave 6 and 8 respectively, while reactions of 3 with acetylacetone gave 7. Synthesis of tetracyclic compounds 9a-f and 11 from the reactions of 3 with ethyl orthoformate or appropriate acids, acid chloride, carbon disulphide and/or ethyl chloroformate. Also its reaction with isothiocyanate derivatives gave the corresponding thiosemicarbzides 12a,b which on, refluxing in alcoholic KOH gave the unexpected tetracyclic products 14a,b. Similarly the tetracyclic compounds 16a-e and 19 were obtained by cyclization of 4 and 18 respectively.
Research Authors
El-Sherief Hassan A.H., El-Naggar Galal M., Hozien Zeinab A., Ei-Sawaisi Suliman M
Research Department
Department of chemistry
Research Journal
Journal of Heterocyclic Chemistry
Research Member
Galal Mostafa ahmed Mousa El-nagar
Research Pages
pp. 467 – 474
Research Rank
2
Research Vol
Vol. 45, No. 2
Research Year
2008
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