Dean's Tour to Monitor Postgraduate Examinations First Semester of the 2025/2026 Academic Year

Under the auspices of Professor Dr. Ahmed El-Menshawy, University President, and Professor Dr. Gamal Badr, Vice President for Postgraduate Studies and Research, Professor Dr. Gihan Nabil Fetih, Dean of the Faculty, accompanied by Professor Dr. Dina Fathallah Mohamed, Vice Dean for Postgraduate Studies and Research, conducted an inspection tour to monitor the progress and smooth running of the first semester postgraduate examinations for the 2025/2026 academic year. The purpose of the tour was to ensure adherence to all regulations governing the examination process.

This tour took place on Sunday, February 8, 2026.

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خبر عام

Rational design of 2-substituted thio-7-chloroquinazolin-4(3H)-one derivatives as dual EGFR/VEGFR-2 inhibitors with broad-Spectrum anticancer and apoptotic activities

Research Abstract

A novel series of 2-substituted thio-7-chloroquinazolin-4(3H)-one derivatives was rationally designed, synthesized, and evaluated as dual inhibitors of epidermal growth factor receptor (EGFR) and vascular endothelial growth factor receptor-2 (VEGFR-2) with potential anticancer activity. Structural optimization was achieved through the incorporation of diverse linkers and pharmacophoric motifs, including aryl amides, hydrazones, chalcones, and heterocyclic moieties, to target key kinase binding domains. In vitro screening against the NCI-60 human tumor cell line panel revealed several compounds with broad-spectrum antiproliferative activity, among which the chalcone derivative (11a) emerged as the most potent. Compound (11a) exhibited low micromolar GI₅₀ values, high selectivity towards cancer cells over normal cells, and strong dual inhibition of EGFR and VEGFR-2 in the nanomolar range. Mechanistic studies demonstrated that (11a) induced G₁/S phase cell cycle arrest, activated apoptotic pathways, suppressed receptor phosphorylation, and promoted PARP-1 cleavage. Notably, (11a) retained inhibitory activity against clinically relevant EGFR resistance mutants, including C797S. Molecular docking and dynamics simulations indicated stable, favorable binding within the ATP-binding sites of both kinases. Collectively, these findings identify compound (11a) as a promising dual-target anticancer lead warranting further preclinical investigation.

Research Authors
Mostafa A. Mansour , Samar H. Abbas , Asmaa M. AboulMagd, Ahmed A. Youssef, Hamdy M. Abdel-Rahman, Mohamed Abdel-Aziz
Research Date
Research Department
Department of Medicinal Chemistry
Research Journal
Bioorganic Chemistry
Research Member
Hamdy Mohamed Mohamed Abdel-Rahman
Research Pages
109562
Research Publisher
Bioorganic Chemistry
Research Rank
Q1
Research Vol
172
Research Website
https://www.sciencedirect.com/science/article/abs/pii/S0045206826000982
Research Year
2026

✨ Congratulations ✨

Prof. Dr. Gihan Nabil Hassan Fetih – Dean of the Faculty,
the Vice Deans, Heads of Departments, and the Faculty Secretary
extend their sincere congratulations
to faculty members and their assistants, staff, and students
on the occasion of the commencement of the second semester
of the academic year 2025/2026,
wishing them a successful academic year filled with excellence and creativity, God willing.

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Meeting of the committee for community and environmental development at the Faculty of Pharmacy This will take place on Monday, February 9, 2026.

God willing, a meeting of the committee for community and environmental development of the Faculty will hold a meeting This will take place on Monday, February 9, 2026, at 11:00 AM

This will take place in the office of Professor Dr./ Vice Dean of the Faculty for Community Service and Environmental Development to discuss the topics outlined in the agenda that will be presented at that time.

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Meeting of the Council of the Medicinal Chemistry Department, Faculty of Pharmacy It will be held on Sunday, February 8, 2026

God willing, The Medicinal Chemistry Department Council will hold its regular monthly meeting number (494), This will take place on Sunday, February 8, 2026, at 12:00 PM in the department library.

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خبر عام

Meeting of the Council of the Pharmaceutics Department, Faculty of This will take place on Sunday, February 8, 2026.

God willing, the meeting of the Pharmaceutics Department Board of the Faculty of Pharmacy No. (547) This will take place on Sunday, February 8, 2026at 12:30 PM.

in the department board on the third floor under the chairmanship of the Faculty to discuss the topics that we will inform you later.

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Announcement for Pharm-D (Clinical Pharmacy) Program Students: Schedule for the start of the second semester of the academic year 2025/2026

Regarding the schedule for the start of the second semester of the 2025/2026 academic year:

• Registration for second semester courses:

From the start of classes on Sunday, February 8, 2026, until Sunday, February 15, 2026, for one week.

• Add/Drop period:

From Monday, February 16, 2026, until Sunday, February 22, 2026, for the second semester of the 2025/2026 academic year.

• Withdrawal from courses with a full refund:

On Sunday, March 15, 2026.

• Withdrawal from courses without a full refund:

Until Sunday, March 22, 2026.

Students withdrawing after this date will be considered to have failed the course.

 

 

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