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The practical exam for the Applied and Forensic Pharmacognosy course for pharm-D students will be held on Tuesday, April 22, 2025, at the time of the practical session, with each student in his/her laboratory.
The midterm exam for the " Medicinal Plants " course for students of the National University will be held on Tuesday, April 15, 2025, from 9:00 AM to 10:00 AM in Hall (1 & 2) below the lecture halls.
The student seating distribution is as follows:
The mid-term and practical exam for the course of Medicinal Chemistry-2 for students of the semester (6) will be held on Saturday, April 12, 2025, at 11:30 in the department’s laboratories.
It has been decided to hold the practical exam for students in semester 2 of the Pharmacognosy -1 course on Tuesday, April 29, 2025, from 12:00 PM to 1:30 PM in the department’s laboratories.
Note:
• Each student must attend their lab.
• The exam will not be retaken for those absent without an excuse acceptable to the faculty administration.
The practical exam for first-year students in the Pharmacognosy 1 course will be held on Monday, April 28, 2025, from 8:30 a.m. to 10:00 a.m. in the department's laboratories.
Note:
• Each student must attend their lab.
• The exam will not be retaken for those absent without an excuse acceptable to the faculty administration.
The practical exam for students of the First National University, Pharmacognosy 1 course, will be held on Saturday, April 26, 2025, from 8:30 to 10:00 a.m. and from 10:30 to 1:00 p.m.
Note:
• Each student must adhere to their assigned time and lab.
• The exam will not be retaken for those absent without an acceptable excuse from the faculty administration.
FimH is a mannose-recognizing lectin that is expressed by Escherichia coli guiding its ability to adhere and infect cells. It is involved in pathogenesis of urinary tract infections and Chron’s disease. Several X-ray structure-guided ligand design studies were extensively utilized in the discovery and optimization of small molecule aryl man noside FimH antagonists. These antagonists retain key specific interactions of the mannose scaffolds with the FimH carbohydrate recognition domains. Thiomannosides are attractive and stable scaffolds, and this work re ports the synthesis of some of their new aryl and heteroaryl derivatives as FimH antagonists. FimH-competitive binding assays as well as biofilm inhibition of the new compounds (24–32) were determined in comparison with the reference n-heptyl α D-mannopyranoside (HM). The affinity among these compounds was found to be gov erned by the structure of the aryl and heteroarylf aglycones. Two compounds 31 and 32 revealed higher activity than HM. Molecular docking and total hydrophobic to topological polar surface area ratio calculations attributed to explain the obtained biological results. Finally, the SAR study suggested that introducing an aryl or heteroaryl aglycone of sufficient hydrophobicity and of proper orientation within the tyrosine binding site considerably enhance binding affinity. The potent and synthetically feasible FimH antagonists described herein hold potential as leads for the development of sensors for detection of E. coli and treatment of its diseases.
