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Congenital heart disease consider one of the most common pediatric chronic disease that can have an improve on the lives of affected children and their families. This study aimed to identify the quality of life among school- age children with congenital heart disease. Materials and Method: Convenience sampling of one hundred school-age children with congenital heart disease and their mothers were selected from outpatient clinic and inpatient pediatric cardiac departments at Assuit University El-Orrman Hospital. The children's age ranged from 8 to 12 years & free from any associated disease. Three tools were used for gathering data in this study; tool (1): A structured interview questionnaire, it involved characteristic and clinical data of children connected to congenital heart disease. Tool (2) Pediatric Quality of Life Inventory scale used to assess the influence of congenital heart disease on child’s quality of life. Tool (3) Socio-economic scale; used to assess the socio-economic status of the children with congenital heart disease. Results shown that more than three quarters of school-age children with congenital heart disease had a neutral quality of life and less than quarter of them had high. Only small percent of studied subjects had poor. Children 's parents' reports established such results, where there were significant positive correlations among children reports and their parents reports in the majority of studied items regarding congenital heart disease .Conclusion the study decided that, there were significant positive correlations between children reports and those of their mothers in the majority of the studied items of quality of life concerning congenital heart disease Therefore, it is recommended to conduct health education program for school-age children who had congenital heart disease and their parents to the different measures of high quality of life is recommended to aid those children to improvement their quality of life.