| Faculty of Medicine

RNA Techniques Workshop

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2 March 2022

The efficacy and safety of extended adjuvant temozolomide following concurrent radio-chemotherapy among Egyptian patients with newly diagnosed glioblastoma multiforme

Read more about The efficacy and safety of extended adjuvant temozolomide following concurrent radio-chemotherapy among Egyptian patients with newly diagnosed glioblastoma multiforme

Research Authors

Alia M Attia, Hanan A Eltybe, Mayada F Sedik, Ahmed Mubarak Hefni, Marwa I Abdelgawad, Ashraf Farrag, Abdelhakeem A Essa, Mohamed M El-Barody, Noha M Attia

Research Journal

American Journal of Cancer Research

Research Member

Marwa Ismail Khalaf Abdel-Gawad

Ashraf Farrag Mohamed Farrag

Abdel-Hakim Abdel-Sattar Abdel-Hakim Issa

Research Publisher

e-Century Publishing Corporation

Research Year

2022

Announcing the Quality Assurance and Qualification Center courses for accreditation during the month of March 2022

Read more about Announcing the Quality Assurance and Qualification Center courses for accreditation during the month of March 2022

1 March 2022

Peri-procedural outcome of series of 104 carotid artery stenting procedures

Read more about Peri-procedural outcome of series of 104 carotid artery stenting procedures

Research Authors

CT Mohamad Ashraf Ahmada, , , , Salah Sayed Attaa, Carmelo Sgroib, Antonino ...

Research Date

Wed, 1 Jan 2014 - 12:00

Research Department

Department of Cardiology

Research Journal

The Egyptian Heart Journal 66 (Issue 2, June 2014,), Pages 163

Research Member

Mohamad Ashraf Ahmed Hussein El-Sherif

COVID-19 pandemic, mechanical reperfusion and 30-day mortality in ST elevation myocardial infarction.

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Research Abstract

Abstract

Objective: The initial data of the International Study on Acute Coronary Syndromes - ST Elevation Myocardial Infarction COVID-19 showed in Europe a remarkable reduction in primary percutaneous coronary intervention procedures and higher in-hospital mortality during the initial phase of the pandemic as compared with the prepandemic period. The aim of the current study was to provide the final results of the registry, subsequently extended outside Europe with a larger inclusion period (up to June 2020) and longer follow-up (up to 30 days).

Methods: This is a retrospective multicentre registry in 109 high-volume primary percutaneous coronary intervention (PPCI) centres from Europe, Latin America, South-East Asia and North Africa, enrolling 16 674 patients with ST segment elevation myocardial infarction (STEMI) undergoing PPPCI in March/June 2019 and 2020. The main study outcomes were the incidence of PPCI, delayed treatment (ischaemia time >12 hours and door-to-balloon >30 min), in-hospital and 30-day mortality.

Results: In 2020, during the pandemic, there was a significant reduction in PPCI as compared with 2019 (incidence rate ratio 0.843, 95% CI 0.825 to 0.861, p<0.0001). This reduction was significantly associated with age, being higher in older adults (>75 years) (p=0.015), and was not related to the peak of cases or deaths due to COVID-19. The heterogeneity among centres was high (p<0.001). Furthermore, the pandemic was associated with a significant increase in door-to-balloon time (40 (25-70) min vs 40 (25-64) min, p=0.01) and total ischaemia time (225 (135-410) min vs 196 (120-355) min, p<0.001), which may have contributed to the higher in-hospital (6.5% vs 5.3%, p<0.001) and 30-day (8% vs 6.5%, p=0.001) mortality observed during the pandemic.

Conclusion: Percutaneous revascularisation for STEMI was significantly affected by the COVID-19 pandemic, with a 16% reduction in PPCI procedures, especially among older patients (about 20%), and longer delays to treatment, which may have contributed to the increased in-hospital and 30-day mortality during the pandemic.

Trial registration number: NCT04412655.

Keywords: COVID-19; myocardial infarction; percutaneous coronary intervention.

Research Authors

Giuseppe De Luca 1 2 , Magdy Algowhary 3 , Berat Uguz 4 , Dinaldo C Oliveira 5 , Vladimir Ganyukov 6 , Zan Zimbakov 7 , Miha Cercek 8 , Lisette Okkels Jensen 9 , Poay Huan Loh 10 , Lucian Calmac 11 , Gerard Roura-Ferrer 12 , Alexandre Quadros

Research Date

Tue, 1 Mar 2022 - 12:00

Research Department

Department of Cardiology

Research Image