Abstract
Giardiasis is one of commonest intestinal protozoa causing diarrheal worldwide especially in daycare centers. The present study aimed to detect prevalence of G. lamblia and its risk factors among
children by using stained microscopic smears and immunochromatographic test. A cross-sectional
study was carried out among 100 children (4 to 15 years) suffered from diarrhea at Pediatric Outpatient Clinics, Aswan University Hospitals. Sheet was filled out one each child or his parents as to name,
sex, age, and previous history of giardiasis. All samples were examined by ICT, and microscopy
The results showed that the prevalence of giardiasis among children was 49%, & 41% by using
stained microscopic examination and rapid ICT (Epituub USA) respectively. Sensitivity and specificity of rapid test were (77.6% & 94.1%) respectively without cross-reactivity with other parasites, with
potentially useful rapid test in absence of unqualified lab technician or in epidemiologic surveys. Giardiasis is more prevalent in rural areas’ children than in urban ones.
Key words: Children, Giardiasis, Diagnosis Microscopy, Immunochromatographic tes
Aim The study aimed at studying the hepatoprotective effect of l-carnitine against lead (Pb) acetate-induced hepatocellular injury, emphasizing the role of caspase-3 and glycogen synthase kinase-3β in hepatocellular apoptosis and inflammation. Materials and methods Male Wistar rats were used. The experimental approach involved estimation of the liver enzymes' serum levels. Oxidative and inflammatory biomarkers were measured in hepatic tissue homogenates. Paraffin-embedded hepatic sections were prepared for histopathology and immunohistochemistry. Quantitative determination of the phosphorylated glycogen synthase kinase-3 beta was performed. Key findings The serum showed a significant elevation in ALT, AST, and LDH; tissue homogenates showed significant elevation in lipid peroxide and inflammatory biomarkers with significant reduction in reduced glutathione in the Pb acetate-treated group
Ginkgo Biloba leaf extract (Egb-761) is used for treating various inflammatory disease conditions therefore this study was performed.
The present study aimed at comparing the ameliorative effects of both systemic and topical Egb-761 versus dexamethasone on carrageenan-induced hind paw inflammation in rats.
Wistar albino rats were injected with carrageenan solution in the sub-planter region of the right hind paw. Egb-761 and dexamethasone were administered systemically to two groups while Egb-761 ointment 2% and dexamethasone sodium phosphate ointment were applied topically for another two groups. Vernier Caliper was used to assess rat paw thickness. Tissue malondialdehyde (MDA), nitric oxide (NO), and tumor necrosis factor-α (TNF-α) levels have been estimated.
Carrageenan induced a significant rat paw edema and …