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Purpose: To evaluate outcomes and prognostic factors in locally advanced non-small cell lung cancer (NSCLC) patients treated with concomitant chemoradiotherapy followed by consolidation with docetaxel and cisplatin in a prospective phase II study. Patients and methods: From January 2012 to March 2014, patients with stage III unresectable NSCLC were treated with thoracic radiotherapy 60 Gy in 30 fractions and weekly 20 mg/m2 docetaxel and 20 mg/m2 cisplatin concomitantly. Consolidation chemotherapy using docetaxel 75 mg/m2 and cisplatin 60 mg/m2 every 3 weeks for 3 cycles followed local therapy in all patients. Results: A total of 46 patients were included in this study. Four (8.7%) patients achieved complete response and 27 (58.7%) patients showed partial response. The median follow-up was 14 months (range: 5-48months) the median overall survival (OS) and progression-free survival were 17 months and 7 months respectively. Esophagitis in 4 (8.7%) patients, neutropenia in 3 (6.5%) patients and peumonitis in 4 (8.7%) patients developed as grade III-IV toxicity due to concomitant chemoradiotherapy (CRT). Tumor stage (p=0.003) and clinical tumor response (p=0.001) were the significant prognostic factors for OS. Conclusion: Concurrent CRT using weekly docetaxel and cisplatin followed by consolidation chemotherapy is effective and well tolerated in patients with stage III NSCLC. Clinical tumor response was significantly associated wit OS, so further investigations regarding the factors associated with improving tumor response would be required.

serological diagnosis of hydatosis in camel and human

This study was conducted to evaluate the combined disc test and the double disc synergy test for MBL detection among imipenem sensitive and resistant A. baumanni strains, to study the co-resistance to other classes of antibiotics and to determine the prevalence of some antibiotic resistance determinants (bla OXA 51 like gene and class I integron) among these isolates. We isolated a total of 51 A. baumannii strains. The antibiotic sensitivity pattern was determined by Kirby Bauer disc diffusion method. For imipenem, the minimum inhibitory concentrations (MICs) were determined using the Epsilometer (E test). The isolates were tested for the presence of MBLs by the combined disc test (CDT) and the double disc synergy test (DDST). For all isolates, PCR was performed for the detection of the bla OXA-51-like and Class I integrase genes. The highest rates of resistance were against ciprofloxacin (64.7%), amoxacillin clavulanic acid (58.8%), amikacin (58.8%), ceftriaxone (56.9%) and chloramphenicol (52.9%). Lower rates of resistance were to imipenem (31.4%) and tetracyclines (25.5%). MBLs were detected in both imipenem sensitive and resistant A. baumannii isolates. The CDT had a sensitivity ranging from 92% to 100% , while the DDST had a sensitivity ranging from 86.2% to 100%. The bla OXA-51 like gene was detected in 96.1% and Class I integrase gene was detected in (72.5%) of A. baumannii strains . The later conferred significantly higher resistance rates to various antibiotics.

This study was conducted to evaluate the combined disc test and the double disc synergy test for MBL detection among imipenem sensitive and resistant A. baumanni strains, to study the co-resistance to other classes of antibiotics and to determine the prevalence of some antibiotic resistance determinants (bla OXA 51 like gene and class I integron) among these isolates. We isolated a total of 51 A. baumannii strains. The antibiotic sensitivity pattern was determined by Kirby Bauer disc diffusion method. For imipenem, the minimum inhibitory concentrations (MICs) were determined using the Epsilometer (E test). The isolates were tested for the presence of MBLs by the combined disc test (CDT) and the double disc synergy test (DDST). For all isolates, PCR was performed for the detection of the bla OXA-51-like and Class I integrase genes. The highest rates of resistance were against ciprofloxacin (64.7%), amoxacillin clavulanic acid (58.8%), amikacin (58.8%), ceftriaxone (56.9%) and chloramphenicol (52.9%). Lower rates of resistance were to imipenem (31.4%) and tetracyclines (25.5%). MBLs were detected in both imipenem sensitive and resistant A. baumannii isolates. The CDT had a sensitivity ranging from 92% to 100% , while the DDST had a sensitivity ranging from 86.2% to 100%. The bla OXA-51 like gene was detected in 96.1% and Class I integrase gene was detected in (72.5%) of A. baumannii strains . The later conferred significantly higher resistance rates to various antibiotics.

This study was conducted to evaluate the combined disc test and the double disc synergy test for MBL detection among imipenem sensitive and resistant A. baumanni strains, to study the co-resistance to other classes of antibiotics and to determine the prevalence of some antibiotic resistance determinants (bla OXA 51 like gene and class I integron) among these isolates. We isolated a total of 51 A. baumannii strains. The antibiotic sensitivity pattern was determined by Kirby Bauer disc diffusion method. For imipenem, the minimum inhibitory concentrations (MICs) were determined using the Epsilometer (E test). The isolates were tested for the presence of MBLs by the combined disc test (CDT) and the double disc synergy test (DDST). For all isolates, PCR was performed for the detection of the bla OXA-51-like and Class I integrase genes. The highest rates of resistance were against ciprofloxacin (64.7%), amoxacillin clavulanic acid (58.8%), amikacin (58.8%), ceftriaxone (56.9%) and chloramphenicol (52.9%). Lower rates of resistance were to imipenem (31.4%) and tetracyclines (25.5%). MBLs were detected in both imipenem sensitive and resistant A. baumannii isolates. The CDT had a sensitivity ranging from 92% to 100% , while the DDST had a sensitivity ranging from 86.2% to 100%. The bla OXA-51 like gene was detected in 96.1% and Class I integrase gene was detected in (72.5%) of A. baumannii strains . The later conferred significantly higher resistance rates to various antibiotics.

This study was conducted to evaluate the combined disc test and the double disc synergy test for MBL detection among imipenem sensitive and resistant A. baumanni strains, to study the co-resistance to other classes of antibiotics and to determine the prevalence of some antibiotic resistance determinants (bla OXA 51 like gene and class I integron) among these isolates. We isolated a total of 51 A. baumannii strains. The antibiotic sensitivity pattern was determined by Kirby Bauer disc diffusion method. For imipenem, the minimum inhibitory concentrations (MICs) were determined using the Epsilometer (E test). The isolates were tested for the presence of MBLs by the combined disc test (CDT) and the double disc synergy test (DDST). For all isolates, PCR was performed for the detection of the bla OXA-51-like and Class I integrase genes. The highest rates of resistance were against ciprofloxacin (64.7%), amoxacillin clavulanic acid (58.8%), amikacin (58.8%), ceftriaxone (56.9%) and chloramphenicol (52.9%). Lower rates of resistance were to imipenem (31.4%) and tetracyclines (25.5%). MBLs were detected in both imipenem sensitive and resistant A. baumannii isolates. The CDT had a sensitivity ranging from 92% to 100% , while the DDST had a sensitivity ranging from 86.2% to 100%. The bla OXA-51 like gene was detected in 96.1% and Class I integrase gene was detected in (72.5%) of A. baumannii strains . The later conferred significantly higher resistance rates to various antibiotics.

Two series of new 2-[4-((1H-benzimidazol-2-ylthio)methyl)-1H-1,2,3-triazol-1-yl]N`-(arylmethylidene) acetohydrazides (4-14) and 2-[4-((1H-benzimidazol-2-ylthio)methyl)-1H-1,2,3-triazol-1-yl]N`-(α-arylethylidene) acetohydrazides (15-20) were prepared by the reaction of 2-[4-((1H-benzimidazol-2-ylthio)methyl)-1H-1,2,3-triazol-1- yl]acetohydrazide (3) and the appropriate (un) substituted benzaldehyde or acetophenones. The purity of all new compounds was checked by TLC and elucidation of their structures was confirmed by IR, 1H NMR, and mass spectrometry along with elemental microanalyses. All the target compounds were evaluated for their possible antimicrobial activity. Most of the tested compounds showed moderate to good antibacterial activity against most of the bacterial strains used in comparison with ciprofloxacin as a reference drug. The most active compounds were (7), (13), (15), and (20). Results of antifungal activity revealed that all compounds showed a good and potent antifungal activity in comparison to fluconazole as a reference drug. Compounds (8), (9), (13) and (14) were the most active compounds

Two series of new 2-[4-((1H-benzimidazol-2-ylthio)methyl)-1H-1,2,3-triazol-1-yl]N`-(arylmethylidene) acetohydrazides (4-14) and 2-[4-((1H-benzimidazol-2-ylthio)methyl)-1H-1,2,3-triazol-1-yl]N`-(α-arylethylidene) acetohydrazides (15-20) were prepared by the reaction of 2-[4-((1H-benzimidazol-2-ylthio)methyl)-1H-1,2,3-triazol-1- yl]acetohydrazide (3) and the appropriate (un) substituted benzaldehyde or acetophenones. The purity of all new compounds was checked by TLC and elucidation of their structures was confirmed by IR, 1H NMR, and mass spectrometry along with elemental microanalyses. All the target compounds were evaluated for their possible antimicrobial activity. Most of the tested compounds showed moderate to good antibacterial activity against most of the bacterial strains used in comparison with ciprofloxacin as a reference drug. The most active compounds were (7), (13), (15), and (20). Results of antifungal activity revealed that all compounds showed a good and potent antifungal activity in comparison to fluconazole as a reference drug. Compounds (8), (9), (13) and (14) were the most active compounds