Background P wave dispersion (PWD) consistitute a recent contribution to the field of non invasive electrocardiography. It is an electrocardiography measurement, which reflect a disparity in atrial conduction. Atrial fibrillation (AF) is the most important risk factor for stroke; it has a deleterious effect on longevity with doubling of all cause mortality. The estimation of the probability of recurrent AF by using a simple parameter might guide the clinician in the management of these patients. Objective To asses the value of PWD as a predictor of AF recurrence in patient with successful cardioversion to sinus rhythm. patient and methods: Sixty two patients who had recent onset AF and successfully converted to sinus rhythm were included. They were followed up for recurrence of AF for six months. All patients were subjected to the following: through history, clinical examination, standard 12 lead ECG for PWD calculation, Echo-doppler to measure LA diameter, left ventricular systolic and diastolic function. Results According to af recurrence, the patients were classified into: Group 1 included 36 patients with recurred AF and Group !1 included 26 patients with persevered sinus rhythm (PSR). Maximum p wave duration was significantly longer in group 1 than in group 11(p 0.04). PWD was significantly higher in group 1(71 ± 21 ms) than those in group 11(40 ± 15 ms)(p 0.000) with sensitivity of 75% and specify of 88.5% at cutoff point >80.5 ms.Statistically significant left ventricular diastolic dysfunction (in the form of impaired and pseudo normal relaxation) and increased left atrial diameter were mor obvious in group 1 than those in group 11(p 0.000 and P, 0.007 respectively). Logistic regression analysis for p max, PWD, LAD and EF% revealed that PWD is independent predictor for recurrence (r = 0.585, p 0.000). Conclusion PWD measured from the ECG may be considered one of the predictor for AF recurrence.

Background: Pyospermia is a common finding in infertile men with controversial issues about its significance Objective: To evaluate effect of pyospermia on computerized semen (CASA) parameters, sperm DNA integrity and chromosomal aneuploidy in infertile men. Subjects: The study included 50 infertile men with oligoasthenoteratozoospermia divided into 2 groups according to presence or absence of pyospermia. Methods: The study included clinical evaluation, peroxidase stain, CASA, sperm DNA evaluation with acridine orange test and sperm FISH analysis of 18, x and Y chromosomes. Main outcome measure: Comparison between the infertile men with and without pyospermia in sperm CASA parameters, DNA fragmentation with acridine orange test and aneuploidy by FISH. Also, to correlate between the number of pus cells and these parameters. Results: Infertile men with pyospermia had significantly lower sperm progressive and total motility percentages. Also, dynamic motility parameters by CASA including curvilinear, straight line, average pathway velocities, straightness, and amplitude of lateral head displacement were significantly lower with pyospermia. Sperm DNA fragmentation index by AOT was significantly higher with pyospermia. Percentages of sperms with disomy XY and 18 by FISH were higher with pyospermia. These changes in sperm motility parameters and DNA integrity correlated with the number of peroxidase positive leukocytes. Conclusions: Pyospermia has a negative impact on sperm motility parameters and DNA integrity regardless infertility as a cofactor.

Background: Pyospermia is a common finding in infertile men with controversial issues about its significance Objective: To evaluate effect of pyospermia on computerized semen (CASA) parameters, sperm DNA integrity and chromosomal aneuploidy in infertile men. Subjects: The study included 50 infertile men with oligoasthenoteratozoospermia divided into 2 groups according to presence or absence of pyospermia. Methods: The study included clinical evaluation, peroxidase stain, CASA, sperm DNA evaluation with acridine orange test and sperm FISH analysis of 18, x and Y chromosomes. Main outcome measure: Comparison between the infertile men with and without pyospermia in sperm CASA parameters, DNA fragmentation with acridine orange test and aneuploidy by FISH. Also, to correlate between the number of pus cells and these parameters. Results: Infertile men with pyospermia had significantly lower sperm progressive and total motility percentages. Also, dynamic motility parameters by CASA including curvilinear, straight line, average pathway velocities, straightness, and amplitude of lateral head displacement were significantly lower with pyospermia. Sperm DNA fragmentation index by AOT was significantly higher with pyospermia. Percentages of sperms with disomy XY and 18 by FISH were higher with pyospermia. These changes in sperm motility parameters and DNA integrity correlated with the number of peroxidase positive leukocytes. Conclusions: Pyospermia has a negative impact on sperm motility parameters and DNA integrity regardless infertility as a cofactor.

Background: Pyospermia is a common finding in infertile men with controversial issues about its significance Objective: To evaluate effect of pyospermia on computerized semen (CASA) parameters, sperm DNA integrity and chromosomal aneuploidy in infertile men. Subjects: The study included 50 infertile men with oligoasthenoteratozoospermia divided into 2 groups according to presence or absence of pyospermia. Methods: The study included clinical evaluation, peroxidase stain, CASA, sperm DNA evaluation with acridine orange test and sperm FISH analysis of 18, x and Y chromosomes. Main outcome measure: Comparison between the infertile men with and without pyospermia in sperm CASA parameters, DNA fragmentation with acridine orange test and aneuploidy by FISH. Also, to correlate between the number of pus cells and these parameters. Results: Infertile men with pyospermia had significantly lower sperm progressive and total motility percentages. Also, dynamic motility parameters by CASA including curvilinear, straight line, average pathway velocities, straightness, and amplitude of lateral head displacement were significantly lower with pyospermia. Sperm DNA fragmentation index by AOT was significantly higher with pyospermia. Percentages of sperms with disomy XY and 18 by FISH were higher with pyospermia. These changes in sperm motility parameters and DNA integrity correlated with the number of peroxidase positive leukocytes. Conclusions: Pyospermia has a negative impact on sperm motility parameters and DNA integrity regardless infertility as a cofactor.

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