Computed tomography (CT) cannot differentiate benign from malignant pulmonary lesion.Diffusion weighted magnetic resonance imaging(DW-MRI) can evaluate lung cancer using ADC which is inveresly correlated to tissue cellularity. Objective: To evaluate the role of measurement of ADC in the differentiation between benign and malignant pulmonary lesions. Patients&Methods: 42 patients with pulmonary masses were included in this study. They underwent diffusion weighted MRI. ADC value measurement and histopathological diagnosis were done for each lesion. Results: The mean age for the studied patients was 57.85± 10.6 years with male predominance (34 patients). On histopathological bases they were subdivided into benign (12 patients) and malignant (30patients).The mean ADCx10-3 for the malignant lesions(0.92±0.15) was significantly(p0.001) lower than benign lesions(1.55 ± 0.15) as shown in Figure1 In malignant tumors, ADC value for small cell lung cancer was significantly(p0.05) lower than non small cell lung cancer . Using ADC value of 1.10x10-3 mm2/s as the cut-off threshold for the differentiation between benign and malignant lesions the sensitivity, specificity, PPV and NPP were 96.7% and 83.3%, 93.5% and 90.9% respectively. Conclusion: Diffusion weighted MRI with measurement of ADC value is very helpful in the differentiation between malignant and benign pulmonary lesions

Computed tomography (CT) cannot differentiate benign from malignant pulmonary lesion.Diffusion weighted magnetic resonance imaging(DW-MRI) can evaluate lung cancer using ADC which is inveresly correlated to tissue cellularity. Objective: To evaluate the role of measurement of ADC in the differentiation between benign and malignant pulmonary lesions. Patients&Methods: 42 patients with pulmonary masses were included in this study. They underwent diffusion weighted MRI. ADC value measurement and histopathological diagnosis were done for each lesion. Results: The mean age for the studied patients was 57.85± 10.6 years with male predominance (34 patients). On histopathological bases they were subdivided into benign (12 patients) and malignant (30patients).The mean ADCx10-3 for the malignant lesions(0.92±0.15) was significantly(p0.001) lower than benign lesions(1.55 ± 0.15) as shown in Figure1 In malignant tumors, ADC value for small cell lung cancer was significantly(p0.05) lower than non small cell lung cancer . Using ADC value of 1.10x10-3 mm2/s as the cut-off threshold for the differentiation between benign and malignant lesions the sensitivity, specificity, PPV and NPP were 96.7% and 83.3%, 93.5% and 90.9% respectively. Conclusion: Diffusion weighted MRI with measurement of ADC value is very helpful in the differentiation between malignant and benign pulmonary lesions

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An isolated fraction with bradykinin potentiating activity, from the venom of the Egyptian scorpion Buthus occitanus, was injected i.p. in female mice (35 days old). Five days after the injection of a single sublethal dose (1 μg/g), the number of primary multilaminar and secondary follicles of the ovaries was increased. Graafian follicles were observed in 50% of the treated mice but in none of the control mice. The number and size of the uterine glands and endometrium were increased in treated mice. Concomitantly, estradiol was increased in the circulating blood, while progesterone was within the normal limits. The enhancement of cellular growth by the isolated venom fraction with bradykinin potentiating activity, could be attributed to an enhancement of some growth factor(s) responsible for stimulating the ovarian follicles and uterus.

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Summary

A method is described for measuring lipid peroxides
by means of the color reagent of a commercially available test kit
for cholesterol estimation. In principle, this assay makes use of
the oxidative capacity of lipid peroxides to convert iodide to
iodine, whic, can be measured photometrically at 365 nm. cdi-
bration curves were obtained using peroxides such as H202,t-butyl
hydroperoxide, and cumene hydroperoxide. A stoichiometric
relationship W ~ Sobserved between the amount of organic perox-
ides assayed and the concentration of iodine produced. Concen-
trations of lipid peroxides as small as 1 nmol/ml could be mea-
sured. The ability to estimate lipid pemxides of isolated low density
lipoprotein was demonstrated.

ABSTRACT Adult T-cell leukemia (ATL) is an oncogenic disease derived from the HTLV-1-infected T cells and there is no effective therapy known yet. We previously reported that down-regulation of N-myc downstream-regulated gene-2 (NDRG2) expression by DNA Methylation and genetic deletion presents one of the most common alterations in adult T-cell leukemia (ATL) and other various kinds of cancers. A stress-induced NDRG2 suppresses important signaling pathways (PI3K and NF-κB) through the de-phosphorylation of PTEN and NIK as a PP2A recruiter. In this manuscript, we identified protein arginine methyltransferase 5 (PRMT5) as a NDRG2/PP2A binding partner. A NDRG2/PP2A complex down-regulated arginine methyltransferase activity of PRMT5 through de-phosphorylation of the serine and threonine residues and changing its co-localization to the nucleus of ATL cell lines increasing the histone arginine methylation; however, PRMT5 was highly phosphorylated and localized in cytoplasm in NDRG2-deficient ATL.

Aim: To present a case of pyelic fusion anomaly with orthotopic kidneys which is extremely rare. For maximum and only, it was reported twice in the literature. Its diagnosis may be unpredictable and it may predispose to major surgical complications. Case report: An 8-year-old child was diagnosed to have a retrocaval ureter which was repaired through a flank incision. A striking finding of a cut and retracted tubular structure was noted during ureteral dissection. Postoperative contralateral perinephric urinoma developed and drained percutaneously. Then, two surgical explorations were done on the left kidney without detection of a cause for urinary extravasation. The left ureter was atretic during explorations. Kidney autotransplantation and ileal reconstructions seemed difficult solutions and nephrectomy was the final step. Discussion: Pyelic fusion anomaly was reported, mainly, in association to renal fusion anomalies like horseshoe and crossed ectopic kidneys. However, it is the first time to report a case of retrocaval ureter in association to pyelic fusion and normally-located and positioned kidneys. Contralateral urinoma after repair of a retrocaval ureter was a striking complication referred to an underlying crossing left-to-right anomalous pathway. This case represented a surgical trap, because it is an extremely rare and unpredictable association of renal anomalies. Conclusion: Pyelic fusion with orthotopic well-positioned kidneys is an extremely rare renal anomaly. Its association to retrocaval ureter makes it extremely unpredictable, especially, when it is undiagnosed preoperatively.