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Radiographic Correlation In Bilateral Impacted Lower Third Molars: A Retrospective CBCT Based Study

Research Abstract

Aim: This study aimed to assess the CBCT based radiographic correlation in bilateral impacted lower third molars so that, if correlated, data available for one side can aid in surgical planning for the other side or justifies the need for additional imaging.

Subjects & methods: DICOM files of 50 cases with bilateral impacted third molar were retrieved and both sides were compared according to four parameters.

Results: Results revealed statistically significant positive correlation between right and left sides regarding impaction angulation, number of roots, and crown caries. Weak correlation was found regarding inferior alveolar canal approximation.

Conclusion: Multicentric larger sample size study with detailed investigations is recommended.

Research Authors
Zein A. Shatat1 , Ahmed T.Temerek2 , Mohamed T. Ellabban3 , Mervat E. A. Refai4 , Ali Fahd5*
Research Date
Research Department
Research File
08-٢.pdf (1.19 MB)
Research Journal
AL-AZHAR Assiut Dental Journal
Research Pages
P. 69:76
Research Publisher
AL-AZHAR Assiut Dental Journal
Research Rank
Local
Research Vol
Vol. 5
Research Year
2022

IMMUNOHISTOCHEMICAL EXPRESSION OF CD44 AND DNA ANALYSIS IN ORAL PREMALIGNANT AND MALIGNANT LESIONS

Research Abstract

Objectives: The aim of the present study is to evaluate CD44 expression to detect cancer stem cell activity along with analyzing the DNA ploidy, to predict the activity of oral carcinogenesis.

Materials and method: Forty formalin fixed paraffin embedded tissues of oral lesions were used and divided equally into 4 groups; different premalignant white lesions, well, moderate, and poorly differentiated squamous cell carcinomas. All specimens were immunostained using CD44 antibodies. Moreover, the same paraffin blocks for each case used to prove the differentiation in DNA ploidy between groups using flow cytometer.

Results: The CD44 immunoexpression showed a marked statistical significant difference between premalignant white lesions and poorly differentiated squamous cell carcinomas. Flow cytometric analysis of DNA parameters between the tested groups revealed a powerful difference of DNA ploidy between the premalignant group and other malignant groups. The S-phase fraction showed significant difference between poorly differentiated OSCC and premalignant lesions with no effective differences between the malignant lesions.

Conclusions: The findings of the present study suggest that the CD44 immunoexpression collaborates with the DNA content analysis presented a real indicator in prediction the behavior of oral premalignant and malignant lesions.
 

Research Authors
Ahmed Hussein; Mohamed Badawy; Hany Gobran; Hesham Dameer; Hazem Abdel-Aleem; Hend Abdel Hamid
Research Date
Research Department
Research File
Research Journal
Egyptian Dental Journal
Research Pages
2265-2274
Research Publisher
The Egyptian Dental Association (EDA)
Research Vol
68
Research Website
https://edj.journals.ekb.eg/article_249015.html
Research Year
2022
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