The mutagenic and carcinogenic heterocyclic amine, 2-amino-3methylimidazo[4,5-f]quinoline (IQ), is produced while cooking protein-rich foods. Mesenchymalstemcells(MSCs)(ascell-basedtherapy)andAnnonamuricata(graviola) (asanaturalproduct)bothpossesspreventivecapacitiesagainst freeradical toxicity in varioustissues.ThisstudyaimstocomparethetherapeuticpropertiesandeffectsofADMSCsandgraviolaonIQ-induced liver toxicityandDNAdamage inrats. Sixtyadult maleratsweredividedintofourgroups:normalunexposedcontrol, IQ, IQ+graviola, and IQ+AD-MSCs. After 6weeks, the ratswere sacrificed, and liver tissueswere examinedforhistopathological changesusinghematoxylin−eosinstaining. p53protein expressionwasevaluatedbyimmunohistochemistry,andDNAdamagewasmeasuredby using the comet test.Our findings indicated thatAD-MSCtherapy led to themost significantimprovementinDNAdamage,apoptosis,andp53,LPO,AST,andALTlevels causedby IQtoxicity. Additionally, AD-MSCs reducedseverehistological alterations (damageandfibrosis)inlivercellsinducedbyIQ.However, theeffectivenessofgraviolatreatment islimited,severelyrestrictingits useforchroniclivertoxicity. Inconclusion, theinitial stageof IQ-inducedlivertoxicityiscausedbyoxidativestress-inducedDNA damage.Comparedwithgraviola,AD-MSCsexhibitmorepotent therapeuticeffectsagainst IQ-inducedliverdamage.