Obesity is associated with abnormal adipokines production and activation of inflammatory signal pathways in adipose tissue. Also, there is rising facts about the relation between the adiponectin function and pathogenesis of type 2 diabetes. The aim of this study is to investigate the relationship between the levels of leptin, adiponectin, tumor necrosis factor alpha (TNF-α) and lymphocytes count in diabetic and obese diabetic participants and its significance in the etiology of diabetes and obesity in Sohag