Announcement for fifth-year Pharm D students: Practical exam for the optional course (Computer-aided Drug Design) will be held.

The practical exam for the elective course
"Computer-Aided Drug Design" for 5th-Year Pharm D students will be held in the computer labs
for Group (A) and Group (B) as follows:

Day

Date

Group

Time

Monday

28/04/2025

Group (A)

12:00 PM

Tuesday

29/04/2025

Group (B)

12:00 PM

All students must attend according to their assigned group and time.
No makeup exam will be given without an officially approved excuse.

اعلان لطلاب الفرقة الخامسة فارم دى سوف يعقد امتحان العملي لمقرر الاختياري (تصميم الدواء بواسطة الحاسوب)

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إعلانات الطلاب

Announcement for First-Year Pharm D and Clinical Pharmacy Students: The second-term mid-term exam and the theoretical and practical exam for the course "Pharmaceutical Organic Chemistry-2" will be held on Saturday, April 26, 2025.

The department announces that the second mid-term exam and the practical theory exam will be held on Saturday, April 26th, from 11:30 AM to 12:30 PM.

Please make sure to attend on time, as the exam will not be repeated.

Venue: Hall 2, beneath Lecture Hall B

Course Content for the mid-term Exam (10 Marks):

  • Prof. Dr. Samia Galal Ahmed's section: “Aldehydes and Ketones” – Lectures 1 and 2
  • Prof. Dr. Ola Ibrahim Abdel Razek's section: “Aliphatic and Aromatic Amines” – Lectures 1 and 2

Course Content for the Practical Theory Exam (15 Marks):

  • All practical sessions
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قسم الكيمياء العضوية

Announcement for First-Year, Clinical Pharmacy, and National University Students: The second-term mid-term exam and the theoretical and practical exam for the course "Pharmaceutical Organic Chemistry-1" will be held on Sunday, May 4, 2025.

The department announces that the second mid-term exam and the second practical theory exam for the course Pharmaceutical Organic Chemistry - 1 (offered course) will be held on Sunday, May 4th, 2025, from 11:30 AM to 12:30 PM.

Please make sure to attend on time, as the exam will not be repeated.

Exam Venues:

  • Pharm D : Hall 1
  • Pharm D National University: Hall 2
  • Pharm D Clinical: Department Lecture Hall

 

اعلان لطلاب الفرقة الأولى وصيدلة اكلينيكية والجامعة الأهلية سوف يعقد امتحان اعمال السنة الثانى وامتحان نظري العملي لمقرر كيمياء عضوية صيدلية-1 يوم الأحد 4 مايو 2025

 

 

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قسم الكيمياء العضوية

Announcement for National University First-Year Students: The practical exam for the course Pharmacognosy-1 will be held on Saturday, April 26, 2025.

The department announces that the second mid-term exam and the second practical theory exam for the course Pharmaceutical Organic Chemistry - 1 (offered course) will be held on Sunday, May 4th, 2025, from 11:30 AM to 12:30 PM.

Please make sure to attend on time, as the exam will not be repeated.

Exam Venues:

  • Pharm D : Hall 1
  • Pharm D National University: Hall 2
  • Pharm D Clinical: Department Lecture Hall

 

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خبر عام

Announcement for First-Year Pharm D Students: The practical exam for the course Pharmacognosy -1 will be held on Monday, April 28, 2025.

The Practical Exam for First-Year Students in the course Pharmacognosy (1) will be held on:

? Monday, April 28th, 2025
? Time: From 8:30 AM to 10:00 AM
? Location: Department Laboratories

Students will be distributed as follows:

Lab

Floor

Student Numbers

Examples of Names

Lab (A)

4th Floor

From 2241002 to 2241038

Abanoub Nasser Ibrahim – Joey Mokhtar Roshdy

Lab (B)

4th Floor

From 2241040 to 2241070

Habiba Sayed Ahmed – Sohaila Khaled Ali Mohamed

Lab (C)

4th Floor

From 2241073 to 2241111

Shahenaz Mohamed Ahmed Othman – Mohamed Yassin Mohamed

Lab (D)

4th Floor

From 2241112 to 2241146

Mahmoud Abdelrahman Abdelrahman Mohamed Abdelkader

Lab (B)

3rd Floor

From 2231005 to 2231110

Ahmed Fawzy Abdel-Aal – Mohamed Gamal Mohamed

? Note:

  • All students must attend in their assigned lab.
  • The exam will not be repeated for any student who is absent without an officially accepted excuse by the faculty administration.
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إعلانات الطلاب

Announcement for Class (10) – Clinical Pharmacy Program it has been decided to hold the theoretical and practical exam for the "Phytotherapy" course on Sunday, April 27, 2025.

Phytotherapy Course – Theoretical and Practical Exam
For Clinical Pharmacy Students – Class (10)

The theoretical and practical exam for the Phytotherapy course will be held as follows:

? Date: Sunday, April 27, 2025
? Time: To be announced later
? Venue: Hall (2), beneath the lecture Halls

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إعلانات الطلاب

Tetrahydrocarbazoles incorporating 5-arylidene-4-thiazolinones as potential antileukemia and antilymphoma targeting tyrosine kinase and tubulin polymerase enzymes: Design, synthesis, structural, biological and molecular docking studies

Research Abstract

Finding effective and selective anticancer agents is a top medical priority due to high clinical treatment demand. However, current anticancer agents have serious side effects and resistance development remains a big concern. This creates an urgent need for new multitarget drugs that could solve these problems. Tetrahydrocarbazoles and 5-arylidene-4-thiazolinones have always attracted researchers for their multifaced anticancer activities and the possibility to be easily derivatized. Thereby, herein we report the combination of the two scaffolds to provide compounds 9a-j and 10a-j that were fully characterized and their tautomeric form was confirmed by crystal structure. 9a-j and 10a-j were assessed for in vitro antiproliferative activity using SRB assay against a panel of seven human cancer cell lines with doxorubicin as the standard. The results revealed that the cell lines derived from leukemia (Jurkat) and lymphoma (U937) are the most sensitive. Compounds 9d, 10e, 10g, and 10f revealed the highest potency (IC 50 (IC 50 = 3.11–11.89 μ M) with much lower effects on normal lymphocytes cell line >50µM). The results show that modifications at 6th position of the THC and the nature of the substituent at the arylidene moiety affect the activity. To exploit the mode of action, 9d, 10e, 10f, and 10g were evaluated as VEGFR-2 and EGFR inhibitors. 10e is the most potent (IC 50 0.26 and 0.14 μ M) against both enzymes. It also induced G0-G1-phase cell cycle arrest and apoptosis. While 10g exhibited higher potency (IC 50 vincristine (IC 50 15.63 μ 9.95 μ M) than M) against tubulin. A molecular docking study was carried out to understand the in teractions between 10e, 10g and their targets. This study reveals 10e and 10g as possible candidates for developing multitarget anticancer agents against leukemia and lymphoma

Research Authors
Basma S. Ali a , Anber F. Mohammed Hajjaj H. M. Abdu-Allah
Research Date
Research Department
Department of Pharmaceutical Organic Chemistry
Research File
1-s2.0-S0045206824007223-main_compressed (1).pdf (866.05 KB)
Research Journal
Bioorganic Chemistry
Research Member
Basma salah Ali
Anber Fangari Mohammed Abdelrahim
Hajjaj Hassan Mohamed Abdu-Allah
Research Publisher
ELSEVIER
Research Vol
153
Research Website
https://www.sciencedirect.com/science/article/pii/S0045206824007223
Research Year
2024
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