Faculty of Pharmacy Family extends its sincere congratulations to the distinguished staff members of the Faculty who were listed in Stanford University’s ranking of the top 2% of the world’s most influential scientists for the year 2025

  • Prof. Mohamed Mahmoud Abdel-Latif – Department of Clinical Pharmacy
  • Prof. Ashraf Mohamed Mahmoud – Department of Pharmaceutical Analytical Chemistry
  • Prof. Bahaa Mohamed Gamal El-Din – Department of Pharmaceutical Organic Chemistry
  • Prof. Hesham Mohamed Tawfik – Department of Industrial Pharmacy
  • Dr. Mahmoud Aboubakr Ahmed Younis – Department of Industrial Pharmacy
  • Dr. Mohamed Mahmoud El-Wakeel – Department of Pharmaceutical Analytical Chemistry

Congratulations and best wishes for continued success

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خبر عام

Discussion of the thesis submitted by Pharmacist/ Mohamed Ahmed Abdel-Baqi Sharqawi - Teaching Assistant in the Department of Pharmaceutical Chemistry and registered to obtain a Master's degree in Pharmaceutical Sciences on Thursday, October 2, 2025

Discussion of the thesis submitted by Pharmacist/ Mohamed Ahmed Abdel-Baqi Sharqawi - Teaching Assistant in the Department of Pharmaceutical Chemistry and registered to obtain a Master's degree in Pharmaceutical Sciences on Thursday, October 2, 2025

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إعلانات الدراسات العليا

Important Announcement for second-year Pharm D (Clinical Pharmacy) students The next lecture of the course “Pharmaceutical Organic Chemistry – 3” will be held on Tuesday, September 30, 2025

اعلان هام لطلاب الفرقة الثانية فارم دى وفارم دى (صيدلة اكلينيكية) سوف يكون موعد المحاضرة القادمة لمقرر كيمياء عضوية صيدلية -3 يوم الثلاثاء 30 سبتمبر 2025

Dr. Ola Mohamed Fahmy Aboughdeir announces that the next lecture will be held, God willing, on Tuesday, September 30, 2025, from 12:00 p.m. to 2:00 p.m. in the lecture hall of the Department of Pharmaceutical Organic Chemistry.

The practical session will take place on Sunday, September 28, 2025, in the lecture halls on the fifth floor of Building (A).

This applies only once (this week only), after which the schedule will return to its regular times in the following week.

Therefore, students are kindly requested to adhere to the announced schedule.

 

news category
إعلانات الطلاب

Important Announcement for Pharm D Students – Allocation of Students into Practical Lessons for the Course "Applied and Forensic Pharmacognosy" (First Semester – Academic Year 2025/2026)

The allocation of students into the practical Lessons will be as follows:

  • First Period: 8:00 – 10:00 a.m.
    • From student ID 2210053 to the last number
    • From student Shereen Ahmed Ahmed Fayyad to the last name
  • Second Period: 10:00 a.m. – 12:00 p.m.
    • From student ID 2210004 to 2211052
    • From student Ahmed Gamal Abdelwahab to student Shorouk Abdo Ibrahim

إعلان هام لطلاب الفارم دي – توزيع الطلاب داخل سكاشكن العملى لمقرر عقاقير تطبيقي وشرعي الفصل الدراسي الأول للعام الجامعى 2025/2026

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إعلانات الطلاب

Final schedule of lectures and practical lessons according to the credit hour system for the Bachelor of Pharmacy (Clinical Pharmacy) for the first semester of the academic year 2025/2026

 

 

Click

?

Link to access lecture schedules

 

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إعلانات الطلاب

The Faculty of Pharmacy concludes its preparations for welcoming the new academic year 2025/2026

تحت رعاية معالى السيد الأستاذ الدكتور / أحمد المنشاوى - رئيس الجامعة ، والسيد الأستاذ الدكتور / أحمد محمد عبدالمولى - نائب رئيس الجامعة لشئون التعليم والطلاب ، قامت السيدة الأستاذ الدكتور / جيهان نبيل فتيح - عميد الكلية ، يرافقها السيد الأستاذ الدكتور / حسن رفعت حسن -وكيل الكلية لشئون التعليم والطلاب ، والسيدة الأستاذ الدكتور/ دينا فتح الله محمد _ وكيل الكلية لشئون الدراسات العليا والبحوث، بعمل جولة تفقدية للمدرجات والمعامل بمختلف الأقسام حيث إطمئنت سيادتها على توفير كافة إحتياجات وإمكانيات العملية التعليمية وعناصر الجودة والإنتهاء من كافة أعمال الصيانة وإعلان الجداول لكل الفرق الدراسية قبل إنطلاق العام الجامعى الجديد 2025/2026 م بما يضمن حسن سير العملية التعليمية على الوجه الأكمل .
تم ذلك يوم السبت الموافق ٢٠٢٥/٩/٢٠

كلية الصيدلة تنهى إستعداداتها لإستقبال العام الجامعى الجديد 2026/2025 م

كلية الصيدلة تنهى إستعداداتها لإستقبال العام الجامعى الجديد 2026/2025 م

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خبر عام

Design, synthesis, molecular modeling, and antiproliferative evaluation of new 2-oxoindolin-3-ylidene thiazole derivatives

Research Abstract

A series of novel 2-oxoindolin-3-ylidene thiazole derivatives were designed and synthesized, inspired by the pharmacophoric features of the VEGFR-2 inhibitor sunitinib. These compounds were evaluated for antiproliferative activity against a panel of sixty cancer cell lines at the US National Cancer Institute, identifying derivatives 4b, 4c, 4d, 4l, and 6c as the most potent, with mean growth inhibition percentages of 118.86%, 135.32%, 148.27%, 126.16%, and 78.46%, respectively. Further cytotoxicity assessments against the HepG2 cell line revealed IC50 values ranging from 3.13 to 30.54 μM. These compounds also demonstrated strong VEGFR-2 inhibition, with IC50 values of 0.113, 0.047, 1.549, 0.995, and 0.089 μM, respectively, compared to sunitinib's IC50 of 0.167 μM. Selectivity index analysis indicated high selectivity for HepG2 cells over THLE-2 normal cells (1.80–10.26), suggesting favourable safety profiles compared to sunitinib (1.15). Notably, compound 4c induced G0/G1 phase cell cycle arrest, promoted apoptosis, upregulated caspase-3 and -9 expression, and delayed wound closure by 60.74%. Molecular docking studies confirmed strong binding interactions within the VEGFR-2 active site, while in silico ADME and DFT analyses supported favourable pharmacokinetic properties and reactivity. These findings position compound 4c as a promising lead for the development of anticancer agents.

Research Authors
Aalaa F. El-Mokadem, Mohammed K. Abd El-Gaber, Pak Hei Chung, Siang-Boon Koh, Hoda Y. Hassan and Adel F. Youssef
Research Date
Research Department
Department of Medicinal Chemistry
Research Image
Research Journal
R S C Medicinal Chemistry
Research Member
Adel Fawzy Yousef Mohiel-Deen
Hoda Youssef Hassan Huosien
Mohamed Khalifa Abdelgaber Khalifa
Aalaa Fathy Bakr Ali
Research Publisher
The Royal Society of Chemistry
Research Rank
Q1
Research Vol
16
Research Website
https://doi.org/10.1039/d5md00332f
Research Year
2025
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