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Discussion of the PhD thesis submitted by Jihan Ahmed Abdel-Hafiz - registered to obtain a doctorate degree in pharmaceutical sciences (medicinal chemistry) on Wednesday, October 1, 2025
Important Announcement for second-year Pharm D (Clinical Pharmacy) students The next lecture of the course “Pharmaceutical Organic Chemistry – 3” will be held on Tuesday, September 30, 2025
Dr. Ola Mohamed Fahmy Aboughdeir announces that the next lecture will be held, God willing, on Tuesday, September 30, 2025, from 12:00 p.m. to 2:00 p.m. in the lecture hall of the Department of Pharmaceutical Organic Chemistry.
The practical session will take place on Sunday, September 28, 2025, in the lecture halls on the fifth floor of Building (A).
This applies only once (this week only), after which the schedule will return to its regular times in the following week.
Therefore, students are kindly requested to adhere to the announced schedule.
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إعلانات الطلاب
Important Announcement for Pharm D Students – Allocation of Students into Practical Lessons for the Course "Applied and Forensic Pharmacognosy" (First Semester – Academic Year 2025/2026)
The allocation of students into the practical Lessons will be as follows:
- First Period: 8:00 – 10:00 a.m.
• From student ID 2210053 to the last number
• From student Shereen Ahmed Ahmed Fayyad to the last name - Second Period: 10:00 a.m. – 12:00 p.m.
• From student ID 2210004 to 2211052
• From student Ahmed Gamal Abdelwahab to student Shorouk Abdo Ibrahim
news category
إعلانات الطلاب
Final schedule of lectures and practical lessons according to the credit hour system for the Bachelor of Pharmacy program for the first semester of the academic year 2025/2026.
Final schedule of lectures and practical lessons according to the credit hour system for the Bachelor of Pharmacy (Clinical Pharmacy) for the first semester of the academic year 2025/2026
The Faculty of Pharmacy concludes its preparations for welcoming the new academic year 2025/2026
تحت رعاية معالى السيد الأستاذ الدكتور / أحمد المنشاوى - رئيس الجامعة ، والسيد الأستاذ الدكتور / أحمد محمد عبدالمولى - نائب رئيس الجامعة لشئون التعليم والطلاب ، قامت السيدة الأستاذ الدكتور / جيهان نبيل فتيح - عميد الكلية ، يرافقها السيد الأستاذ الدكتور / حسن رفعت حسن -وكيل الكلية لشئون التعليم والطلاب ، والسيدة الأستاذ الدكتور/ دينا فتح الله محمد _ وكيل الكلية لشئون الدراسات العليا والبحوث، بعمل جولة تفقدية للمدرجات والمعامل بمختلف الأقسام حيث إطمئنت سيادتها على توفير كافة إحتياجات وإمكانيات العملية التعليمية وعناصر الجودة والإنتهاء من كافة أعمال الصيانة وإعلان الجداول لكل الفرق الدراسية قبل إنطلاق العام الجامعى الجديد 2025/2026 م بما يضمن حسن سير العملية التعليمية على الوجه الأكمل .
تم ذلك يوم السبت الموافق ٢٠٢٥/٩/٢٠
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خبر عام
Design, synthesis, molecular modeling, and antiproliferative evaluation of new 2-oxoindolin-3-ylidene thiazole derivatives
Research Abstract
A series of novel 2-oxoindolin-3-ylidene thiazole derivatives were designed and synthesized, inspired by the pharmacophoric features of the VEGFR-2 inhibitor sunitinib. These compounds were evaluated for antiproliferative activity against a panel of sixty cancer cell lines at the US National Cancer Institute, identifying derivatives 4b, 4c, 4d, 4l, and 6c as the most potent, with mean growth inhibition percentages of 118.86%, 135.32%, 148.27%, 126.16%, and 78.46%, respectively. Further cytotoxicity assessments against the HepG2 cell line revealed IC50 values ranging from 3.13 to 30.54 μM. These compounds also demonstrated strong VEGFR-2 inhibition, with IC50 values of 0.113, 0.047, 1.549, 0.995, and 0.089 μM, respectively, compared to sunitinib's IC50 of 0.167 μM. Selectivity index analysis indicated high selectivity for HepG2 cells over THLE-2 normal cells (1.80–10.26), suggesting favourable safety profiles compared to sunitinib (1.15). Notably, compound 4c induced G0/G1 phase cell cycle arrest, promoted apoptosis, upregulated caspase-3 and -9 expression, and delayed wound closure by 60.74%. Molecular docking studies confirmed strong binding interactions within the VEGFR-2 active site, while in silico ADME and DFT analyses supported favourable pharmacokinetic properties and reactivity. These findings position compound 4c as a promising lead for the development of anticancer agents.
Research Date
Research Department
Research Image
Research Journal
R S C Medicinal Chemistry
Research Member
Research Publisher
The Royal Society of Chemistry
Research Rank
Q1
Research Vol
16
Research Website
https://doi.org/10.1039/d5md00332f
Research Year
2025
