Introduction: Caregiving is a dynamic process which includes patient and a person who is involved in long term care of the patient. This long term care very often leads to experience of burden in the caregivers. It is important to understand caregiver’s coping strategies for tackling burden. Aim: The study aimed to investigate burden and coping strategies among caregivers of mood disorder patients and examine the relationship between burden and coping strategies among them. Design: A descriptive design was utilized in this study. Setting: The study was carried out at inpatient unit at neuropsychiatry and neurosurgical hospital at Assiut University. Sample: The sample comprised of 100 caregivers of mood patients. Tools: Tools of study comprised of personal data questionnaire, mood disorder burden index (MDBI) and ways of coping questionnaire. Results: The highest mean scores of burden of exhibited specific behaviors by patients were related to sleeping too much (2.45 ± 1.52), that patients said there were too many thoughts running through their head (2.05 ± 1.51) and they were more talkative than usual (2.05 ± 1.51). Also, the highest mean scores of the caregivers' burden (Bother or upset) were related to sleeping too much (2.25 ± 1.15), caregivers felt that patients had withdrawn from them (2.10 ± 1.01), caregivers felt that efforts to be helpful to patient when patient was having mood problems were rejected (2.06 ± 1.05) and caregiver felt a loss of companionship or closeness with patient as a result of patient’s mood disorder (2.03 ± 1.20). Regarding coping strategies, the highest mean scores were related to self-controlling (9.89 ± 4.01), positive reappraisal (9.42 ± 3.90) and seeking social support (9.25 ± 4.43) respectively. Self-controlling, planful problem solving and positive reappraisal were positively and significantly correlated with frequency of exhibited specific behaviors by patients (r=0.311, 0.363, &0.245 with p-value = 0.002, 0.000 & 0.014) respectively and caregivers' bother or upset (r= 0.261, 0.416 &0.252 with p-value = 0.009, 0.000 &0.011) respectively. Conclusion: Caregivers of patients with mood disorder experienced high mean scores of burden related to the frequency of symptoms exhibited by patients and caregivers' bother or upset. The highest mean scores of coping strategies utilized by them were related to self-controlling, positive reappraisal and seeking social support. Self-controlling, planful problem solving and positive reappraisal were positively and significantly correlated with some of exhibited specific behaviors by patients and caregivers' bother or upset. Recommendations: Designing and implementing psychoeducational programs are essential for caregivers of patients with mood disorders to provide them stress management skills and healthy coping strategies.