The homeless are socially isolated, cut off from the connections with family, friends and community. They frequently report involvement in antisocial and criminal activities such as street prostitution, drug- dealing, theft and assault in order to survive. The aim of this study was to determine the effect of social skills training program on the communication and social skills of homeless children. The subjects included all homeless children at the homeless shelter for children and men at Assiut City. The subjects included 41 children, 17 of them boys and 24 girls. The age of them was ranged from 9-16 years old. Tools of study: Socio-demographic data questionnaire, communication skills assessment scale and social skills assessment scale. Results of the study revealed that communication and social skills improved immediately post program and at follow up. Conclusion: Social training program has positive effect on communication & social skills of homeless children. Recommendations: Special program regarding social skills training could be established for health care providers who provide care for homeless children especially for nurses.