Background: The effect of association between chronic obstructive pulmonary disease (COPD) and diabetes (DM) on platelet function has not been studied before. Objectives: To evaluate the effect of the association between COPD and DMon platelet function and C reactive protein (CRP). Patients and Methods: This case control study was carried out on 110 stable COPD patients who were classified into diabetic and nondiabetic groups. In addition, 40 apparently healthy, age and sex-matched individuals were included in this study as a control group. Chest X-ray, pulmonary function testing and arterial blood gases were done for COPD patients. CRP and complete blood count (CBC) were measured in both patient and control groups. Results: Mean platelet volume (MPV), platelet distribution width (PDW), platelet crit (PCT) and CRP were significantly higher in COPD patients either nondiabetic or diabetic compared to control group. Moreover, MPVand CRP markers were significantly higher in COPD diabetic patients compared to nondiabetic. There was no significant difference in various laboratory data among different stages of COPD either diabetic or nondiabetic (P>0.05). In COPD patients, MPV was a significantly positively correlated with CRP and PDW(r50.346, P0.001; r50.510, P0.001, respectively) and negatively correlated with PLT count (r520.294, P50.002). Conclusion: MPV, PDW, PCT and CRP were significantly higher in COPD patients either nondiabetic or diabetic. Platelet function may be modified by the systemic inflammation that associated with COPD. Platelet activation as a prothrombotic sequence of this disease may be used as novel therapeutic target. Please cite this paper as: Makhlouf HA, Sadek SH and Nafady AA. Platelet function in diabetic and nondiabetic patients with chronic obstructive pulmonary disease: a case control study. Clin Respir J 2016; 00: 000–000 DOI:10.1111/crj.12477.

OBJECTIVE: The hand measurements were carried out on both hands and all fingers of each volunteer to perform a standard for the Aswan population and to correlate the hand length with the body height. MATERIAL AND METHODS: Hand print impressions of 1000 adult Aswanian volunteers (500 males and 500 females) were taken. They are right handed. All volunteers were from Aswan governate by both parents.Their ages were from 18-20 years old. They have good health and free of any chronic debilitating disease. The parameters studied were maximum length and breadth of both hands and for each finger of both hands. Hand Index (maximum hand width / hand length X 100) and finger Index (maximum finger width / finger length X 100) for each finger were estimated. For estimation of body height a Height Measuring Stand was used. The all measurements were done at fixed time from 9 am to 11 am to avoid the diurnal variation the data were analyzed statistically. RESULTS: The hand parameters in the male were found to be statistically significant longer and broader than the female. A symmetrical male and female hands were found. A significant correlation between the body height and all hand parameters were found, the greater correlation was found with the hand length. A generalized multiple regression equation has been designed to estimate stature from values of hand length and hand breadth in Aswanians regardless of sex or laterality in the form: S (stature) = 55.3 + 5.5 HL + 1.9 HB ± 5.1. This equation may be helpful to obtain approximate stature when there is difficulty in obtaining a direct measurement of the body height. CONCLUSION: Variations in hand measurements and body height may be attributed to several factors like genetic, racial, geographical, climatic and nutritional.

OBJECTIVE: The hand measurements were carried out on both hands and all fingers of each volunteer to perform a standard for the Aswan population and to correlate the hand length with the body height. MATERIAL AND METHODS: Hand print impressions of 1000 adult Aswanian volunteers (500 males and 500 females) were taken. They are right handed. All volunteers were from Aswan governate by both parents.Their ages were from 18-20 years old. They have good health and free of any chronic debilitating disease. The parameters studied were maximum length and breadth of both hands and for each finger of both hands. Hand Index (maximum hand width / hand length X 100) and finger Index (maximum finger width / finger length X 100) for each finger were estimated. For estimation of body height a Height Measuring Stand was used. The all measurements were done at fixed time from 9 am to 11 am to avoid the diurnal variation the data were analyzed statistically. RESULTS: The hand parameters in the male were found to be statistically significant longer and broader than the female. A symmetrical male and female hands were found. A significant correlation between the body height and all hand parameters were found, the greater correlation was found with the hand length. A generalized multiple regression equation has been designed to estimate stature from values of hand length and hand breadth in Aswanians regardless of sex or laterality in the form: S (stature) = 55.3 + 5.5 HL + 1.9 HB ± 5.1. This equation may be helpful to obtain approximate stature when there is difficulty in obtaining a direct measurement of the body height. CONCLUSION: Variations in hand measurements and body height may be attributed to several factors like genetic, racial, geographical, climatic and nutritional.

OBJECTIVE: The hand measurements were carried out on both hands and all fingers of each volunteer to perform a standard for the Aswan population and to correlate the hand length with the body height. MATERIAL AND METHODS: Hand print impressions of 1000 adult Aswanian volunteers (500 males and 500 females) were taken. They are right handed. All volunteers were from Aswan governate by both parents.Their ages were from 18-20 years old. They have good health and free of any chronic debilitating disease. The parameters studied were maximum length and breadth of both hands and for each finger of both hands. Hand Index (maximum hand width / hand length X 100) and finger Index (maximum finger width / finger length X 100) for each finger were estimated. For estimation of body height a Height Measuring Stand was used. The all measurements were done at fixed time from 9 am to 11 am to avoid the diurnal variation the data were analyzed statistically. RESULTS: The hand parameters in the male were found to be statistically significant longer and broader than the female. A symmetrical male and female hands were found. A significant correlation between the body height and all hand parameters were found, the greater correlation was found with the hand length. A generalized multiple regression equation has been designed to estimate stature from values of hand length and hand breadth in Aswanians regardless of sex or laterality in the form: S (stature) = 55.3 + 5.5 HL + 1.9 HB ± 5.1. This equation may be helpful to obtain approximate stature when there is difficulty in obtaining a direct measurement of the body height. CONCLUSION: Variations in hand measurements and body height may be attributed to several factors like genetic, racial, geographical, climatic and nutritional.

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Background: Lung cancer is one of the leading causes of mortality in the world. The main reason for poor lung cancer prognosis is that the patients are often diagnosed in late stages with advanced disease. The expression of some miRNAs has been reported to be involved in diagnosis, classification and prognosis of lung cancer. This study aimed to evaluate the role of plasma miRNA 155 and miRNA 197 in lung cancer. Subjects and methods: This study included sixty lung cancer patients and twenty apparently healthy individuals. Complete blood picture, kidney and liver function tests, serum glucose, lactate dehydrogenase, and carcinoembryonic antigen (CEA) were done by standard methods. Plasma miRNA 155 and miRNA 197 were done by Real-time polymerase chain reaction. Results: There were significant elevations in serum CEA and plasma miRNA155 and miRNA197 in lung cancer patients compared to control group. miRNA155 and miRNA197 showed significant elevation with advanced tumor stage and metastasis. CEA at cutoff (28 ng/ml) resulted in 74% sensitivity. MiRNA 155 at cutoff (152 fold changes) resulted in 93% sensitivity. MiRNA 197 at cutoff (159.18 fold changes) resulted in 90% sensitivity. The specificity was 100% for all. Combined use of miRNA155, miRNA197 and CEA increased the sensitivity to 94.8%. Conclusion: Plasma miRNA 155 and miRNA197 are more sensitive than CEA as tumor markers for lung cancer. They are correlated with tumor stage and presence of metastasis but not correlated with histological types.

Background: Lung cancer is one of the leading causes of mortality in the world. The main reason for poor lung cancer prognosis is that the patients are often diagnosed in late stages with advanced disease. The expression of some miRNAs has been reported to be involved in diagnosis, classification and prognosis of lung cancer. This study aimed to evaluate the role of plasma miRNA 155 and miRNA 197 in lung cancer. Subjects and methods: This study included sixty lung cancer patients and twenty apparently healthy individuals. Complete blood picture, kidney and liver function tests, serum glucose, lactate dehydrogenase, and carcinoembryonic antigen (CEA) were done by standard methods. Plasma miRNA 155 and miRNA 197 were done by Real-time polymerase chain reaction. Results: There were significant elevations in serum CEA and plasma miRNA155 and miRNA197 in lung cancer patients compared to control group. miRNA155 and miRNA197 showed significant elevation with advanced tumor stage and metastasis. CEA at cutoff (28 ng/ml) resulted in 74% sensitivity. MiRNA 155 at cutoff (152 fold changes) resulted in 93% sensitivity. MiRNA 197 at cutoff (159.18 fold changes) resulted in 90% sensitivity. The specificity was 100% for all. Combined use of miRNA155, miRNA197 and CEA increased the sensitivity to 94.8%. Conclusion: Plasma miRNA 155 and miRNA197 are more sensitive than CEA as tumor markers for lung cancer. They are correlated with tumor stage and presence of metastasis but not correlated with histological types.

Background: Lung cancer is one of the leading causes of mortality in the world. The main reason for poor lung cancer prognosis is that the patients are often diagnosed in late stages with advanced disease. The expression of some miRNAs has been reported to be involved in diagnosis, classification and prognosis of lung cancer. This study aimed to evaluate the role of plasma miRNA 155 and miRNA 197 in lung cancer. Subjects and methods: This study included sixty lung cancer patients and twenty apparently healthy individuals. Complete blood picture, kidney and liver function tests, serum glucose, lactate dehydrogenase, and carcinoembryonic antigen (CEA) were done by standard methods. Plasma miRNA 155 and miRNA 197 were done by Real-time polymerase chain reaction. Results: There were significant elevations in serum CEA and plasma miRNA155 and miRNA197 in lung cancer patients compared to control group. miRNA155 and miRNA197 showed significant elevation with advanced tumor stage and metastasis. CEA at cutoff (28 ng/ml) resulted in 74% sensitivity. MiRNA 155 at cutoff (152 fold changes) resulted in 93% sensitivity. MiRNA 197 at cutoff (159.18 fold changes) resulted in 90% sensitivity. The specificity was 100% for all. Combined use of miRNA155, miRNA197 and CEA increased the sensitivity to 94.8%. Conclusion: Plasma miRNA 155 and miRNA197 are more sensitive than CEA as tumor markers for lung cancer. They are correlated with tumor stage and presence of metastasis but not correlated with histological types.

Background: Lung cancer is one of the leading causes of mortality in the world. The main reason for poor lung cancer prognosis is that the patients are often diagnosed in late stages with advanced disease. The expression of some miRNAs has been reported to be involved in diagnosis, classification and prognosis of lung cancer. This study aimed to evaluate the role of plasma miRNA 155 and miRNA 197 in lung cancer. Subjects and methods: This study included sixty lung cancer patients and twenty apparently healthy individuals. Complete blood picture, kidney and liver function tests, serum glucose, lactate dehydrogenase, and carcinoembryonic antigen (CEA) were done by standard methods. Plasma miRNA 155 and miRNA 197 were done by Real-time polymerase chain reaction. Results: There were significant elevations in serum CEA and plasma miRNA155 and miRNA197 in lung cancer patients compared to control group. miRNA155 and miRNA197 showed significant elevation with advanced tumor stage and metastasis. CEA at cutoff (28 ng/ml) resulted in 74% sensitivity. MiRNA 155 at cutoff (152 fold changes) resulted in 93% sensitivity. MiRNA 197 at cutoff (159.18 fold changes) resulted in 90% sensitivity. The specificity was 100% for all. Combined use of miRNA155, miRNA197 and CEA increased the sensitivity to 94.8%. Conclusion: Plasma miRNA 155 and miRNA197 are more sensitive than CEA as tumor markers for lung cancer. They are correlated with tumor stage and presence of metastasis but not correlated with histological types.

Background: Lung cancer is one of the leading causes of mortality in the world. The main reason for poor lung cancer prognosis is that the patients are often diagnosed in late stages with advanced disease. The expression of some miRNAs has been reported to be involved in diagnosis, classification and prognosis of lung cancer. This study aimed to evaluate the role of plasma miRNA 155 and miRNA 197 in lung cancer. Subjects and methods: This study included sixty lung cancer patients and twenty apparently healthy individuals. Complete blood picture, kidney and liver function tests, serum glucose, lactate dehydrogenase, and carcinoembryonic antigen (CEA) were done by standard methods. Plasma miRNA 155 and miRNA 197 were done by Real-time polymerase chain reaction. Results: There were significant elevations in serum CEA and plasma miRNA155 and miRNA197 in lung cancer patients compared to control group. miRNA155 and miRNA197 showed significant elevation with advanced tumor stage and metastasis. CEA at cutoff (28 ng/ml) resulted in 74% sensitivity. MiRNA 155 at cutoff (152 fold changes) resulted in 93% sensitivity. MiRNA 197 at cutoff (159.18 fold changes) resulted in 90% sensitivity. The specificity was 100% for all. Combined use of miRNA155, miRNA197 and CEA increased the sensitivity to 94.8%. Conclusion: Plasma miRNA 155 and miRNA197 are more sensitive than CEA as tumor markers for lung cancer. They are correlated with tumor stage and presence of metastasis but not correlated with histological types.