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Abstract Background Warts are common viral skin infections caused by human papillomavirus. None of the available treatment modalities fulfills the criteria of an ideal treatment option. Objectives To evaluate the efficacy and safety of hydrogen peroxide (HP) 3% and 6% solution as a topical treatment of nongenital warts. Methods This prospective randomized controlled study included 145 patients with nongenital warts. They were divided into three groups. Group 1 used topical hydrogen peroxide 6% solution under occlusion with a plastic tape for one hour daily for 6 weeks, group 2 used hydrogen peroxide 3% solution, and group 3 used normal saline 0.9% as a placebo. Patients were evaluated at the third and sixth weeks of treatment and 12 weeks after treatment completion. Results Treatment responses were significantly better in groups 1 and 2 than in group 3 with a better overall responses in group 1 than in group 2 (P = 0.0001*). Apart from mild hypopigmentation which was detected in only two patients in groups 1 and 2, no other side effects could be detected. Three months after treatment completion, no recurrence was observed. Conclusion Hydrogen peroxide solution (3% and 6%) is an effective, safe, and cheap treatment modality for nongenital warts which can be used simply at home. Since the overall response was better with the 6% concentration, it should be the better therapeutic option.

Abstract Background Warts are common viral skin infections caused by human papillomavirus. None of the available treatment modalities fulfills the criteria of an ideal treatment option. Objectives To evaluate the efficacy and safety of hydrogen peroxide (HP) 3% and 6% solution as a topical treatment of nongenital warts. Methods This prospective randomized controlled study included 145 patients with nongenital warts. They were divided into three groups. Group 1 used topical hydrogen peroxide 6% solution under occlusion with a plastic tape for one hour daily for 6 weeks, group 2 used hydrogen peroxide 3% solution, and group 3 used normal saline 0.9% as a placebo. Patients were evaluated at the third and sixth weeks of treatment and 12 weeks after treatment completion. Results Treatment responses were significantly better in groups 1 and 2 than in group 3 with a better overall responses in group 1 than in group 2 (P = 0.0001*). Apart from mild hypopigmentation which was detected in only two patients in groups 1 and 2, no other side effects could be detected. Three months after treatment completion, no recurrence was observed. Conclusion Hydrogen peroxide solution (3% and 6%) is an effective, safe, and cheap treatment modality for nongenital warts which can be used simply at home. Since the overall response was better with the 6% concentration, it should be the better therapeutic option.

Abstract Background Warts are common viral skin infections caused by human papillomavirus. None of the available treatment modalities fulfills the criteria of an ideal treatment option. Objectives To evaluate the efficacy and safety of hydrogen peroxide (HP) 3% and 6% solution as a topical treatment of nongenital warts. Methods This prospective randomized controlled study included 145 patients with nongenital warts. They were divided into three groups. Group 1 used topical hydrogen peroxide 6% solution under occlusion with a plastic tape for one hour daily for 6 weeks, group 2 used hydrogen peroxide 3% solution, and group 3 used normal saline 0.9% as a placebo. Patients were evaluated at the third and sixth weeks of treatment and 12 weeks after treatment completion. Results Treatment responses were significantly better in groups 1 and 2 than in group 3 with a better overall responses in group 1 than in group 2 (P = 0.0001*). Apart from mild hypopigmentation which was detected in only two patients in groups 1 and 2, no other side effects could be detected. Three months after treatment completion, no recurrence was observed. Conclusion Hydrogen peroxide solution (3% and 6%) is an effective, safe, and cheap treatment modality for nongenital warts which can be used simply at home. Since the overall response was better with the 6% concentration, it should be the better therapeutic option.

Abstract Background Warts are common viral skin infections caused by human papillomavirus. None of the available treatment modalities fulfills the criteria of an ideal treatment option. Objectives To evaluate the efficacy and safety of hydrogen peroxide (HP) 3% and 6% solution as a topical treatment of nongenital warts. Methods This prospective randomized controlled study included 145 patients with nongenital warts. They were divided into three groups. Group 1 used topical hydrogen peroxide 6% solution under occlusion with a plastic tape for one hour daily for 6 weeks, group 2 used hydrogen peroxide 3% solution, and group 3 used normal saline 0.9% as a placebo. Patients were evaluated at the third and sixth weeks of treatment and 12 weeks after treatment completion. Results Treatment responses were significantly better in groups 1 and 2 than in group 3 with a better overall responses in group 1 than in group 2 (P = 0.0001*). Apart from mild hypopigmentation which was detected in only two patients in groups 1 and 2, no other side effects could be detected. Three months after treatment completion, no recurrence was observed. Conclusion Hydrogen peroxide solution (3% and 6%) is an effective, safe, and cheap treatment modality for nongenital warts which can be used simply at home. Since the overall response was better with the 6% concentration, it should be the better therapeutic option.

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Little is known on the pulmonary gradients of oxyhemoglobin, carboxyhemoglobin and methemoglobin in pulmonary arterial hypertension (PAH). We sought to determine these gradients in group 1 PAH and assess their association with disease severity and survival. During right heart catheterization (RHC) we obtained blood from pulmonary artery (PA) and pulmonary artery wedge (PAW) positions and used co-oximetry to test their gasometric differences. We included a total of 130 patients, 65 had group 1 PAH, 40 had pulmonary hypertension (PH) from groups 2–5 and 25 had no PH during RHC. In all groups, PAW blood had higher pH, carboxyhemoglobin and lactate as well as lower pCO2 than PA blood. In group 1 PAH (age 58 ± 15 years, 72% females), methemoglobin in the PAW was lower than in the PA blood (0.83% ± 0.43 vs 0.95% ± 0.50, p = 0.03) and was directly associated with the degree of change in pulmonary vascular resistance (R = 0.35, p = 0.02) during inhaled nitric oxide test. Oxyhemoglobin in PA (HR (95%CI): 0.90 (0.82–0.99), p = 0.04) and PAW (HR (95%CI): 0.91 (0.84–0.98), p = 0.003) blood was associated with adjusted survival in PAH. Marked differences were observed in the gasometric determinations between PAW and PA blood. The pulmonary gradient of methemoglobin was lower in PAH patients compared to controls and a higher PAW blood methemoglobin was associated with a more pronounced pulmonary vascular response to inhaled nitric oxide. Pulmonary artery and PAW oxyhemoglobin tracked with disease severity and survival in PAH.

Aim The aim was to evaluate 120-day complete wound healing rates in negative pressure wound therapy (NPWT) versus conventional dressings in anatomically challenging areas (the heel and ankle regions). Patients and methods A retrospective, cohort study that included diabetic patients having acute (30 days) challenging wounds at the area of the heel and ankle after surgical debridement and achieved complete wound healing or 120-day follow-up whichever occurs first. Forty-four patients were identified and were divided into two groups according to the method of wound therapy. Group A (NPWT, n=18) and group B (conventional moist daily dressings, n=26). The primary end point was complete wound healing rates within 120 days. Distribution of characteristics between study groups and healing rates among different risk groups were reported. Kaplan–Meier curve on the basis of time-to-event strategy followed by a log rank test to measure difference among study groups were performed. Results Complete wound healing within a 120-day assessment period was achieved in 72.3% (group A) and 30.8% in group B (P=0.019). There was no overall significant difference in the distribution of characteristics among two groups except for BMI (P=0.03) and albumin level (0.02). However, HgA1c levels (P=0.01) and wound treatment method (P=0.007) were only factors that significantly affected the healing rate. Conclusion On the basis of current data analysis, the use of NPWT should be recommended for acute diabetic foot wounds in the heel and ankle regions to obtain faster complete healing and desired wound closure in such critical areas.

Aim The aim was to evaluate 120-day complete wound healing rates in negative pressure wound therapy (NPWT) versus conventional dressings in anatomically challenging areas (the heel and ankle regions). Patients and methods A retrospective, cohort study that included diabetic patients having acute (30 days) challenging wounds at the area of the heel and ankle after surgical debridement and achieved complete wound healing or 120-day follow-up whichever occurs first. Forty-four patients were identified and were divided into two groups according to the method of wound therapy. Group A (NPWT, n=18) and group B (conventional moist daily dressings, n=26). The primary end point was complete wound healing rates within 120 days. Distribution of characteristics between study groups and healing rates among different risk groups were reported. Kaplan–Meier curve on the basis of time-to-event strategy followed by a log rank test to measure difference among study groups were performed. Results Complete wound healing within a 120-day assessment period was achieved in 72.3% (group A) and 30.8% in group B (P=0.019). There was no overall significant difference in the distribution of characteristics among two groups except for BMI (P=0.03) and albumin level (0.02). However, HgA1c levels (P=0.01) and wound treatment method (P=0.007) were only factors that significantly affected the healing rate. Conclusion On the basis of current data analysis, the use of NPWT should be recommended for acute diabetic foot wounds in the heel and ankle regions to obtain faster complete healing and desired wound closure in such critical areas.