Sarcoptic mange, commonly known as scabies, is a highly contagious skin condition caused by the burrowing mite Sarcoptes scabiei (Astigmata: Sarcoptinae). This parasitic disease significantly impacts livestock and human health, particularly in underserved regions. Current treatments rely on synthetic acaricides like permethrin and ivermectin, which suffer from limitations such as toxicity, resistance development, and environmental contamination. Essential oils from Apiaceae plants represent a promising natural alternative. This study reviewed 122 volatile constituents from Apiaceae plants and conducted comprehensive in silico analyses to identify potential antiparasitic agents. Geraniol emerged as a potent acaricidal candidate due to its strong binding affinity to acetylcholinesterase (AChE) (docking score: − 7.85 kcal/mol). In vitro testing revealed geraniol achieved a 100% mite mortality rate at concentrations as low as 6.25% within 15 min (LT₅₀ = 9.5 min). In vivo studies using scabies-infected rabbits demonstrated that geraniol-treated animals exhibited complete clinical recovery by two weeks post-treatment, with disappearance of crusts, itching, and skin thickening. Histopathological examination showed near-complete skin regeneration with minimal inflammatory infiltrates, in contrast to control groups which exhibited severe lesions and active mite presence. Furthermore, geraniol-treated rabbits displayed new hair growth and improved general condition, with no observed adverse effects. These findings highlight geraniol’s potential as a safe, effective, and eco-friendly treatment for scabies, offering a 100% improvement in clinical and histological recovery within two weeks. Further research should focus on optimizing delivery systems and evaluating its efficacy in human clinical trials.

Background and AimSurgical trauma is known to cause peripheral and central sensitization and hyperalgesia, which if untreated can cause chronic postoperative pain after surgery. The current work was conducted to evaluate the effect of preoperative pregabalin 150 mg orally on opioid consumption and acute postoperative pain in spinal fusion surgery.MethodsOver one-year duration between 2020 and 2021, the current study was conducted. Ninety patients who were scheduled for spinal fusion surgeries (single and double levels) were recruited and randomly subdivided into two equal groups who received either pregabalin or placebo. The primary outcome was the overall amount of consumed morphine in the first 24 hours postoperatively. Secondary outcomes included VAS score at 1 hour, 2 hours, 4 hours and 24 hours postoperative, time to first rescue analgesia and vital signs including heart rate and mean arterial blood pressure intra- and postoperatively.

High inspired oxygen concentrations (FiO2) are claimed to cause resorption atelectasis increasing the risk for perioperative hypoxemia and postoperative pulmonary complications. Pediatric physicians are still reluctant to accomplish low FiO2 strategies in children. We investigated the association between lung ultrasound score (LUS) and arterial oxygenation (PaO2/FiO2 ratio)in anesthetized mechanically ventilated children undergoing non-abdominal surgery using different FiO2 fractions.