Hemolytic disease of the newborn (HDN) is a disorder caused by antibodies from mother that pass through the placenta and attack red blood cells of fetus. Although other blood groups may potentially be implicated, Rh or ABO blood group incompatibility are the most common cause of this illness. Even though they are rarely linked to neonatal hyperbilirubinemia, minor blood group incompatibilities resulting from blood types other than Rh (D) are considered risk for significant jaundice and its complications in neonates if they are not properly identified and treated. In order to help clinicians reduce infant morbidity and improve overall patient care, the study's goal was to identify instances at elevated risk.