Serum periostin and eotaxin-2 as promising biomarkers in asthmatic smokers.

Background: Smoking influence many changes in asthmatic airway inflammation by stimulating the production of certain cytokines. Serum periostin and eotaxin-2 in asthmatic patients are affected by smoking.

Objectives: The purpose of this study was to study serum periostin and eotaxin-2 level in asthmatic smokers.

Patients and methods: The present observational, cross sectional study was conducted at Chest department in Assiut university hospital, during the period from August 2018 to January 2020. Hundred and seventeen asthmatic patients (42 smokers, 30 ex-smokers and 45 non-smokers) were studied for serum periostin and eotaxin-2 (ELISA). The effects of smoking status and inflammatory biomarkers including sputum eosinophilic and neutrophilic count on serum level of periostin and eotaxin-2 in asthmatic patients were …